Evidence map›Paper›PMID 34207166›Full record

ArticleInternational journal of molecular sciences2021

Expression Profiling and Bioinformatics Analysis of CircRNA in Mice Brain Infected with Rabies Virus.

Wen Zhao, Jingyin Su, Ningning Wang, Naiyu Zhao, Shuo Su

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Wen ZhaoCollege of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
Jingyin SuCollege of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
Ningning WangCollege of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
Naiyu ZhaoCollege of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
Shuo SuCollege of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
Nanjing Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rabies virus (RABV) induces acute, fatal encephalitis in mammals including humans. The circRNAs are important in virus infection process, but whether circRNAs regulated RABV infection remains largely unknown. Here, mice brain with or without the RABV CVS-11 strain were subjected to RNA sequencing and a total of 30,985 circRNAs were obtained. Among these, 9021 candidates were shared in both groups, and 14,610 and 7354 circRNAs were expressed specifically to the control and experimental groups, indicating that certain circRNAs were specifically inhibited or induced on RABV infection. The circRNAs mainly derived from coding exons. In total, 636 circRNAs were differentially expressed in RABV infection, of which 426 significantly upregulated and 210 significantly downregulated (

Indexed as

Computational BiologyGene Expression ProfilingRabies virusRNA, CircularAnimalsBrainGene Expression RegulationGene Regulatory NetworksHost-Pathogen InteractionsMiceMicroRNAsRabiesRNA InterferenceRNA, MessengerTranscriptomeMicroRNAsRNA, CircularRNA, MessengerceRNA networkcircRNAsenrichment analysismice brainrabies virus

Identifiers

PMID34207166
PMCPMC8234020
OpenAlexW3176376258

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.