Evidence map›Paper›PMID 34207162›Full record

ReviewPharmaceuticals (Basel, Switzerland)2021

Confocal Microscopy and Anterior Segment Optical Coherence Tomography Imaging of the Ocular Surface and Bleb Morphology in Medically and Surgically Treated Glaucoma Patients: A Review.

Carmela Carnevale, Ivano Riva, Gloria Roberti, Manuele Michelessi, Lucia Tanga, Alice C Verticchio Vercellin, Luca Agnifili, Gianluca Manni, Alon Harris, Luciano Quaranta and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in Pharmaceuticals (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Non-invasiveBiomedical optics express · 2023
    Article
  3. Review
  4. Glaucoma and Dry Eye Disease: Opportunity to Assess and Treat.Clinical ophthalmology (Auckland, N.Z.) · 2023
    Review
  5. Commentary: Evaluating ocular surface disease in glaucoma.Indian journal of ophthalmology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Carmela CarnevaleIRCCS-Fondazione Bietti, Rome, Via Livenza, 3, 00198 Rome, Italy.
Ivano RivaDepartment of Surgical & Clinical, Diagnostic and Pediatric Sciences, Section of Ophthalmology, University of Pavia-IRCCS Fondazione Policlinico San Matteo, 27100 Pavia, Italy.ORCID 0000-0002-7397-2260
Gloria RobertiIRCCS-Fondazione Bietti, Rome, Via Livenza, 3, 00198 Rome, Italy.
Manuele MichelessiIRCCS-Fondazione Bietti, Rome, Via Livenza, 3, 00198 Rome, Italy.
Lucia TangaIRCCS-Fondazione Bietti, Rome, Via Livenza, 3, 00198 Rome, Italy.
Alice C Verticchio VercellinDepartment of Ophthalmology, Icahn School of Medicine at Mount Sinai Hospital, New York, NY 10029, USA.
Luca AgnifiliOphthalmology Clinic, Department of Medicine and Aging Science, University G. d'Annunzio of Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0002-1625-6305
Gianluca ManniIRCCS-Fondazione Bietti, Rome, Via Livenza, 3, 00198 Rome, Italy.
Alon HarrisDepartment of Ophthalmology, Icahn School of Medicine at Mount Sinai Hospital, New York, NY 10029, USA.
Luciano QuarantaDepartment of Surgical & Clinical, Diagnostic and Pediatric Sciences, Section of Ophthalmology, University of Pavia-IRCCS Fondazione Policlinico San Matteo, 27100 Pavia, Italy.
Francesco OddoneIRCCS-Fondazione Bietti, Rome, Via Livenza, 3, 00198 Rome, Italy.
Fondazione G.B. Bietti · ITMount Sinai Hospital · USUniversity of Pavia · ITUniversity of Chieti-Pescara · ITUniversity of Rome Tor Vergata · IT

Funding

Integration of clinical measures and theoretical modeling to quantify sectorial specific changes in ocular structure, function, and hemodynamicsR01EY030851 · NEI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ARCIERO, JULIA, HARRIS, ALON · 2020 to 2023
$1.3M
NEI NIH HHS R01 EY030851
6 · The paper itself

Abstract

Glaucoma patients often suffer from ocular surface disease (OSD) caused by the chronic administration of topical anti-glaucoma medications, especially in cases of long-term therapy with preserved or multiple drugs. Additionally, glaucoma surgery may determine ocular surface changes related to the formation and location of the filtering bleb, the application of anti-mitotic agents, and the post-operative wound-healing processes within the conjunctiva. Recently, several studies have evaluated the role of advanced diagnostic imaging technologies such as in vivo confocal microscopy (IVCM) and anterior segment-optical coherence tomography (AS-OCT) in detecting microscopic and macroscopic features of glaucoma therapy-related OSD. Their clinical applications are still being explored, with recent particular attention paid to analyzing the effects of new drug formulations and of minimally invasive surgical procedures on the ocular surface status. In this review, we summarize the current knowledge about the main changes of the ocular surface identified at IVCM and AS-OCT in glaucoma patients under medical therapy, or after surgical treatment.

Indexed as

anterior segment optical coherence tomographyglaucomain vivo confocal microscopymedical treatmentocular surfacesurgical treatment

Identifiers

PMID34207162
PMCPMC8234834
OpenAlexW3175598595

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.