ArticleLife (Basel, Switzerland)2021
Aerobic Exercise Decreases Negative Affect by Modulating Orbitofrontal-Amygdala Connectivity in Adolescents.
Article in Life (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 4 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Acute exercise for anxiety reduction in children and adolescents: a meta-analysis of developmental, contextual, and modality-specific effects.European journal of pediatrics · 2026Pooled it
- Pooled it
- A comprehensive systematic review of fMRI studies on brain connectivity in healthy children and adolescents: Current insights and future directions.Developmental cognitive neuroscience · 2024Pooled it
- Mood Status Response to Physical Activity and Its Influence on Performance: Are Chronotype and Exercise Timing Affect?International journal of environmental research and public health · 2023Pooled it
- The bidirectional modulation of acute aerobic exercise on cognitive performance and brain electrical activity in adolescents with smartphone addiction: an experimental study using EEG power spectrum analysis.Frontiers in public health · 2026Trial
- The multiple mediating effects of emotional distress and inhibitory control between physical activity and adolescent internet addiction.Scientific reports · 2026Article
- Habitual Aerobic Exercise Is Associated with Reduced Negative Emotional Elicitation: An fNIRS Study.Brain sciences · 2026Article
- Activity Patterns in Relation to Dynamic Functional Network States: A Longitudinal Feasibility Study of Brain-Behavior Associations in Young Adults.Brain sciences · 2026Article
- Neural evidence for exercise-driven emotional stability via cognitive regulation mechanisms.Frontiers in psychology · 2026Article
- Exercise and Adolescent Flourishing: A Gender-Specific Chain Mediation Model Involving Mindfulness and Rumination.Psychology research and behavior management · 2026Article
- The Moderating Role of Trait Anxiety in the Relationship Between Acute Aerobic Exercise and Cognitive Control in College Students.Depression and anxiety · 2026Article
- From the court to the heart: basketball intervention is associated with adolescents' subjective well-being-a serial mediation analysis of executive function and psychological capital.Frontiers in psychology · 2026Article
- The relationship between family support and Internet addiction among adolescents in Western China: the chain mediating effect of physical exercise and depression.BMC pediatrics · 2025Article
- Article
- An open data for imaging acute aerobic exercise effects on brain and mind in emerging adulthood.Scientific data · 2024Article
- Anxiety and depression are associated with heightened risk of incident deep vein thrombosis: Mediation through stress-related neural mechanisms.American journal of hematology · 2024Article
- Cortico-limbic interactions and carotid atherosclerotic burden during chronic stress exposure.European heart journal · 2024Article
- Effect of Stress-Related Neural Pathways on the Cardiovascular Benefit of Physical Activity.Journal of the American College of Cardiology · 2024Article
- Aerobic exercise promotes emotion regulation: a narrative review.Experimental brain research · 2024Review
- Differential modulation of resting-state functional connectivity between amygdala and precuneus after acute physical exertion of varying intensity: indications for a role in affective regulation.Frontiers in human neuroscience · 2024Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Long-term negative affect in adolescence is associated with impairment in quality of life, interpersonal function, and social adaptation. Although physical exercise could decrease negative emotion, the underlying mechanism remains largely unknown. Acute exercise with controlled intensity might be a good experimental paradigm to unravel the potential neural mechanisms underlying the effects of physical exercise on negative affect. In this study, twenty-three males in late adolescence were randomly assigned to acute exercise group (AG) or control group. The experiment contained pre-test and post-test session interleaved with 30-min moderate-intensity exercise or seated rest. In each session, a resting-state fMRI scanning was conducted followed by completing Positive and Negative Affect Schedule and Profile of Mood State. Bilateral amygdala was used as seed region to calculate t voxel-wised functional connectivity (FC) of amygdala to whole brain. The results demonstrated, for the first time, that AG exhibited increased FC between right amygdala and right orbital frontal cortex. Significantly decreased negative affect was also observed in AG. Moreover, the increased rOFC-amygdala FC was also associated with the decreased depression score. Our findings suggest that exercise-induced decreased negative affect might be modulated by functional interactions of amygdala with both cognitive control and limbic networks, which offers a meaningful insight for clinical treatment and prevention of emotional disorders in late adolescence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.