Evidence map›Paper›PMID 34207117›Full record

ReviewNutrients2021

Remission of Type 2 Diabetes with Very Low-Calorie Diets-A Narrative Review.

Susan Juray, Kathleen V Axen, Steven E Trasino

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 41 citations in OpenAlex.

  1. Clinical and Metabolic Characteristics of Spontaneous Remission in Type 2 Diabetes: A Real-World Study from South India.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2026
    Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Efficacy of a Homemade Very Low Calorie Diet to Achieve Prevention or Remission of Type 2 Diabetes: A Pilot Study.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2025
    Article
  8. Review
  9. Article
  10. Recent progress of remission in type 2 diabetes.Therapeutic advances in endocrinology and metabolism · 2025
    Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Glycaemic Control and Weight Reduction: A Narrative Review of New Therapies for Type 2 Diabetes.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2023
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Susan JurayNutrition Program, School of Urban Public Health, Hunter College, City University of New York, New York, NY 10035, USA.
Kathleen V AxenDepartment of Health and Nutrition Sciences, Brooklyn College, City University of New York, New York, NY 11201, USA.
Steven E TrasinoNutrition Program, School of Urban Public Health, Hunter College, City University of New York, New York, NY 10035, USA.ORCID 0000-0003-1297-3582
City University of New York · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Very low-calorie diets (VLCD) are hypocaloric dietary regimens of approximately 400-800 kcal/day that result in 20-30% reductions in body weight, sometimes in just 12-16 weeks. A body of evidence demonstrates that adherence to VLCD in adults with type 2 diabetes (T2D) can result in marked improvements to glycemic control and even full T2D remission, challenging the convention that T2D is a lifelong disease. Although these data are promising, the majority of VLCD studies have focused on weight loss and not T2D remission as a primary endpoint. Moreover, there is a wide range of VLCD protocols and definitions of T2D remission used across these hypocaloric studies. Together the large degree of heterogeneity in VLCD studies, and how T2D remission is defined, leave many gaps in knowledge to efficacy and durability of VLCD approaches for T2D remission. This narrative review examines findings from a body of data from VLCD studies that specifically sought to investigate T2D remission, and discusses the efficacy of VLCD compared to other hypocaloric approaches, and who is likely to benefit from VLCD approaches for T2D remission.

Indexed as

Body WeightCaloric RestrictionDiabetes Mellitus, Type 2Energy IntakeGlycemic IndexHumansObesityWeight Losshypocaloric dietsremissiontype 2 diabetesvery low calorie diets

Identifiers

PMID34207117
PMCPMC8234895
OpenAlexW3175270726

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.