SynthesisGenes2021
How Depressing Is Inbreeding? A Meta-Analysis of 30 Years of Research on the Effects of Inbreeding in Livestock.
Synthesis in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 120 citations in OpenAlex.
- Quantifying genetic load through joint modelling of inbreeding depression and inbreeding load for litter size in rabbits.Genetics, selection, evolution : GSE · 2026Article
- Genetic diversity and genomic inbreeding trends in the Japanese Thoroughbred population.Journal of equine science · 2026Article
- Heat-load-dependent inbreeding depression for production traits in Italian Holstein cattle.Genetics, selection, evolution : GSE · 2026Article
- Genomic Analysis of Inbreeding Depression on Productive Traits in Rubia Galega Beef Cattle Breed.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2026Article
- Article
- Genetic inbreeding depression load for conformation defects and dressage traits in the Pura Raza Española horse.Animal bioscience · 2026Article
- Linkage- and ROH-based genomic relationship matrices for IBD based management of genetic diversity.Genetics, selection, evolution : GSE · 2026Article
- Genomic analysis of the inbreeding load for body weight, carcass and reproductive traits in the Rubia Gallega beef cattle population.Genetics, selection, evolution : GSE · 2026Article
- Genetic diversity of US Rambouillet in the National Sheep Improvement Program compared to other sheep breeds.The Journal of heredity · 2026Article
- Strategies to improve on selection based on estimated breeding values.Genetics, selection, evolution : GSE · 2026Article
- Emerging trends in genome editing of wild animals.Transgenic research · 2026Review
- Probabilities of two alleles being identity by state at unobserved loci predicted by observed loci in cattle populations.Scientific reports · 2026Article
- Runs of homozygosity in Italian Holstein bulls: a permutation approach and time-based mapping of the genomic regions potentially under selection.BMC genomics · 2026Article
- Genomics and phenomics: Who will be the dairy cows of the future?JDS communications · 2025Review
- Maternal origins and genetic diversity of Sabahan swamp buffalo using mitochondrial cytochrome b gene.Scientific reports · 2025Article
- Comparing Genomic and Pedigree Inbreeding Coefficients in the Slovenian Lipizzan Horse as a Case Study for Small Closed Populations.Animals : an open access journal from MDPI · 2025Article
- Article
- Combining genomics and semen microbiome increases the accuracy of predicting bull prolificacy.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2025Article
- Genetic inbreeding load and its individual prediction for milk yield in French dairy sheep.Genetics, selection, evolution : GSE · 2025Article
- Exploring inbreeding depression in Brazilian Angus cattle population using pedigree and genomic data.Frontiers in genetics · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inbreeding depression has been widely documented for livestock and other animal and plant populations. Inbreeding is generally expected to have a stronger unfavorable effect on fitness traits than on other traits. Traditionally, the degree of inbreeding depression in livestock has been estimated as the slope of the linear regression of phenotypic values on pedigree-based inbreeding coefficients. With the increasing availability of SNP-data, pedigree inbreeding can now be replaced by SNP-based measures. We performed a meta-analysis of 154 studies, published from 1990 to 2020 on seven livestock species, and compared the degree of inbreeding depression (1) across different trait groups, and (2) across different pedigree-based and SNP-based measures of inbreeding. Across all studies and traits, a 1% increase in pedigree inbreeding was associated with a median decrease in phenotypic value of 0.13% of a trait's mean, or 0.59% of a trait's standard deviation. Inbreeding had an unfavorable effect on all sorts of traits and there was no evidence for a stronger effect on primary fitness traits (e.g., reproduction/survival traits) than on other traits (e.g., production traits or morphological traits).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.