ReviewMolecules (Basel, Switzerland)2021
Laccases: Versatile Biocatalysts for the Synthesis of Heterocyclic Cores.
Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 47 citations in OpenAlex.
- Sustainable Biocatalytic Cascades: A Versatile Tool in the Synthesis of Natural Products With Therapeutic Potential.Chembiochem : a European journal of chemical biology · 2026Review
- A chemoenzymatic synthesis of amide-containing quinazolin-4(RSC advances · 2026Article
- Synthesis and Bioactive Properties of the Novel Coloured Compound Obtained via the Laccase-Mediated Transformation of 5-Aminosalicylic Acid.Molecules (Basel, Switzerland) · 2024Article
- Characterization of a New Laccase fromMolecules (Basel, Switzerland) · 2023Article
- Potential of the enzyme laccase for the synthesis and derivatization of antimicrobial compounds.World journal of microbiology & biotechnology · 2023Review
- Laccase-mediated synthesis of bioactive natural products and their analogues.RSC chemical biology · 2022Review
- Review
- Distal Mutations Shape Substrate-Binding Sites during Evolution of a Metallo-Oxidase into a Laccase.ACS catalysis · 2022Article
- Predicting the Redox Potentials of Phenazine Derivatives Using DFT-Assisted Machine Learning.ACS omega · 2022Article
- Bioactive Properties of a Novel Antibacterial Dye Obtained from Laccase-Mediated Oxidation of 8-Anilino-1-naphthalenesulfonic Acid.Molecules (Basel, Switzerland) · 2022Article
- Nano-reduction of gold and silver ions: A perspective on the fate of microbial laccases as potential biocatalysts in the synthesis of metals (gold and silver) nano-particles.Current research in microbial sciences · 2022Review
- Inhibitory Potential of New Phenolic Hydrazide-Hydrazones with a Decoy Substrate Fragment towards Laccase from a Phytopathogenic Fungus: SAR and Molecular Docking Studies.International journal of molecular sciences · 2021Article
- Laccase-Catalyzed Derivatization of Antibiotics with Sulfonamide or Sulfone Structures.Microorganisms · 2021Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Laccases are multicopper oxidases that have shown a great potential in various biotechnological and green chemistry processes mainly due to their high relative non-specific oxidation of phenols, arylamines and some inorganic metals, and their high redox potentials that can span from 500 to 800 mV vs. SHE. Other advantages of laccases include the use of readily available oxygen as a second substrate, the formation of water as a side-product and no requirement for cofactors. Importantly, addition of low-molecular-weight redox mediators that act as electron shuttles, promoting the oxidation of complex bulky substrates and/or of higher redox potential than the enzymes themselves, can further expand their substrate scope, in the so-called laccase-mediated systems (LMS). Laccase bioprocesses can be designed for efficiency at both acidic and basic conditions since it is known that fungal and bacterial laccases exhibit distinct optimal pH values for the similar phenolic and aromatic amines. This review covers studies on the synthesis of five- and six-membered ring heterocyclic cores, such as benzimidazoles, benzofurans, benzothiazoles, quinazoline and quinazolinone, phenazine, phenoxazine, phenoxazinone and phenothiazine derivatives. The enzymes used and the reaction protocols are briefly outlined, and the mechanistic pathways described.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.