Evidence map›Paper›PMID 34206991›Full record

ArticlePolymers2021

Multifactorial Effects of Gelling Conditions on Mechanical Properties of Skin-Like Gelatin Membranes Intended for In Vitro Experimentation and Artificial Skin Models.

Lilian C Alarcón-Segovia, Jorge I Daza-Agudelo, Ignacio Rintoul

Abstract read
In one paragraph

Article in Polymers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Prospects of Coffee Leaf against SARS-CoV-2 Infection.International journal of biological sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lilian C Alarcón-SegoviaInstituto de Desarrollo Tecnológico para la Industria Química, Universidad Nacional del Litoral and Consejo Nacional de Investigaciones Científicas y Técnicas, Santa Fe 3000, Argentina.
Jorge I Daza-AgudeloInstituto de Desarrollo Tecnológico para la Industria Química, Universidad Nacional del Litoral and Consejo Nacional de Investigaciones Científicas y Técnicas, Santa Fe 3000, Argentina.
Ignacio RintoulInstituto de Desarrollo Tecnológico para la Industria Química, Universidad Nacional del Litoral and Consejo Nacional de Investigaciones Científicas y Técnicas, Santa Fe 3000, Argentina.ORCID 0000-0002-0766-9554

Funding

Consejo Nacional de Investigaciones Científicas y Técnicas PIP 1118Fondo para la Investigación Científica y Tecnológica PICT 2015 1785Universidad María Auxiliadora 0002
6 · The paper itself

Abstract

The development of new cosmetic products, skin contact medical devices, skin medicaments, wound care devices, tattooing and piercing has experienced an impressive growth in recent years. In parallel, new restrictions to in vivo experimentation in animals and humans have been widely implemented by regulatory authorities. New knowledge about alternative materials for in vitro skin-related experimentation is required to overcome these severe limitations. This paper presents a set of three 4-D surface response equations describing the mechanical properties of skin-like gelatin membranes intended for use as an alternative biomaterial for in vitro skin-related experimentation. The membranes were obtained by a sol-gel method. The novelty of this contribution is the establishment of the cross-dependency effects of key synthesis conditions on the final mechanical properties of gelatin membranes. The results of this work are useful to produce gelatin membranes with tailored mechanical properties mimicking different types of human skins. In particular, membranes with Young's modulus of 1 MPa and maximum tensile strength of 0.85 MPa were obtained.

Indexed as

animal alternativeanimal-free testingartificial skin modelsskin equivalent

Identifiers

PMID34206991
PMCPMC8234139

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.