Evidence map›Paper›PMID 34206981›Full record

ArticleDiagnostics (Basel, Switzerland)2021

Screening Severe Obstructive Sleep Apnea in Children with Snoring.

Hui-Shan Hsieh, Chung-Jan Kang, Hai-Hua Chuang, Ming-Ying Zhuo, Guo-She Lee, Yu-Shu Huang, Li-Pang Chuang, Terry B-J Kuo, Cheryl C-H Yang, Li-Ang Lee and 1 more

Open access · goldAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Drug-Induced Sleep Endoscopy in Children Predicts OSA Severity.World journal of otorhinolaryngology - head and neck surgery · 2026
    Article
  2. Cost-utility analysis of a tiered diagnostic approach combining a screening model and polysomnography in pediatric obstructive sleep apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
    Article
  3. Gas exchange parameters for the prediction of obstructive sleep apnea in infants.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024
    Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Special Issue: The Diagnosis and Management of OSA.Diagnostics (Basel, Switzerland) · 2022
    Article
  10. Hypertension in Children with Obstructive Sleep Apnea Syndrome-Age, Weight Status, and Disease Severity.International journal of environmental research and public health · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Hui-Shan HsiehSleep Center, Department of Otorhinolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou Main Branch, Taoyuan 33305, Taiwan.ORCID 0000-0002-4181-9798
Chung-Jan KangSleep Center, Department of Otorhinolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou Main Branch, Taoyuan 33305, Taiwan.
Hai-Hua ChuangCollege of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.ORCID 0000-0002-7394-4016
Ming-Ying ZhuoDepartment of Otolaryngology, Xiamen Chang Gung Hospital, Xiamen 361126, China.
Guo-She LeeFaculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan.
Yu-Shu HuangCollege of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.ORCID 0000-0002-4015-5942
Li-Pang ChuangCollege of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.ORCID 0000-0001-5466-8995
Terry B-J KuoInstitute of Brain Science, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan.
Cheryl C-H YangInstitute of Brain Science, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan.
Li-Ang LeeSleep Center, Department of Otorhinolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou Main Branch, Taoyuan 33305, Taiwan.ORCID 0000-0001-8414-595X
Hsueh-Yu LiSleep Center, Department of Otorhinolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou Main Branch, Taoyuan 33305, Taiwan.
Chang Gung University · TWNational Yang Ming Chiao Tung University · TWChang Gung Memorial Hospital · TWNational Taipei University of Technology · TWXiamen Chang Gung Hospital · CN

Funding

Chang Gung Medical Foundation CMRPG3D0771 (H.-Y.L.).Chang Gung Medical Foundation, CMRPG3F1091-3 and CMRPG3J1701 (L.-A.L.)
6 · The paper itself

Abstract

Efficient screening for severe obstructive sleep apnea (OSA) is important for children with snoring before time-consuming standard polysomnography. This retrospective cross-sectional study aimed to compare clinical variables, home snoring sound analysis, and home sleep pulse oximetry on their predictive performance in screening severe OSA among children who habitually snored. Study 1 included 9 (23%) girls and 30 (77%) boys (median age of 9 years). Using univariate logistic regression models, 3% oxygen desaturation index (ODI3) ≥ 6.0 events/h, adenoidal-nasopharyngeal ratio (ANR) ≥ 0.78, tonsil size = 4, and snoring sound energy of 801-1000 Hz ≥ 22.0 dB significantly predicted severe OSA in descending order of odds ratio. Multivariate analysis showed that ODI3 ≥ 6.0 events/h independently predicted severe pediatric OSA. Among several predictive models, the combination of ODI3, tonsil size, and ANR more optimally screened for severe OSA with a sensitivity of 91% and a specificity of 94%. In Study 2 (27 (27%) girls and 73 (73%) boys; median age, 7 years), this model was externally validated to predict severe OSA with an accuracy of 76%. Our results suggested that home sleep pulse oximetry, combined with ANR, can screen for severe OSA more optimally than ANR and tonsil size among children with snoring.

Indexed as

adenoidal-nasopharyngeal ratiochildrenobstructive sleep apneaoxygen desaturation indexsnoring sound energytonsil size

Identifiers

PMID34206981
PMCPMC8304319
OpenAlexW3175169790

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.