Evidence map›Paper›PMID 34206976›Full record

ArticleMolecules (Basel, Switzerland)2021

Discovery of New Pyrazolopyridine, Furopyridine, and Pyridine Derivatives as CDK2 Inhibitors: Design, Synthesis, Docking Studies, and Anti-Proliferative Activity.

Adel A-H Abdel-Rahman, Amira K F Shaban, Ibrahim F Nassar, Dina S El-Kady, Nasser S M Ismail, Samy F Mahmoud, Hanem M Awad, Wael A El-Sayed

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
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  13. Synthesis of 1-Amino-3-oxo-2,7-naphthyridinesInternational journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Adel A-H Abdel-RahmanChemistry Department, Faculty of Science, Menofia University, Shbien El-Kom 32511, Egypt.
Amira K F ShabanChemistry Department, Faculty of Science, Menofia University, Shbien El-Kom 32511, Egypt.
Ibrahim F NassarFaculty of Specific Education, Ain Shams University, Abassia, Cairo 11772, Egypt.
Dina S El-KadyHormone Department, National Research Centre, Dokki, Cairo 12622, Egypt.
Nasser S M IsmailPharmaceutical Chemistry Department, Faculty of Pharmacy, Future University in Egypt, Cairo 12311, Egypt.
Samy F MahmoudDepartment of Biotechnology, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.ORCID 0000-0002-9025-7306
Hanem M AwadTanning Materials and Leather Technology Department, National Research Centre, Dokki, Cairo 12622, Egypt.ORCID 0000-0002-3970-2371
Wael A El-SayedDepartment of Chemistry, College of Science, Qassim University, Buraidah 51452, Saudi Arabia.ORCID 0000-0002-8232-1830

Funding

Taif University, Taif, Saudi Arabia TURSP-2020/138
6 · The paper itself

Abstract

New pyridine, pyrazoloyridine, and furopyridine derivatives substituted with naphthyl and thienyl moieties were designed and synthesized starting from 6-(naphthalen-2-yl)-2-oxo-4-(thiophen-2-yl)-1,2-dihydropyridine-3-carbonitrile (

Indexed as

Antineoplastic AgentsCell Line, TumorCell SurvivalCyclin-Dependent Kinase 2Dose-Response Relationship, DrugDoxorubicinDrug DesignDrug Screening Assays, AntitumorHumansImidazolesInhibitory Concentration 50Molecular Docking SimulationProtein Kinase InhibitorsPyrazolesPyridinesPyrimidinesAntineoplastic AgentsCDK2 protein, humanCyclin-Dependent Kinase 2DoxorubicinimidazoleImidazolesProtein Kinase InhibitorsPyrazolespyrazolo(3,4-b)pyridinepyrazolopyridinePyridinespyrimidinePyrimidinesanticancerCDK2dockingHepG2imidazolepyrazolo[3,4-b]pyridinepyridine

Identifiers

PMID34206976
PMCPMC8272136

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.