Synthesis, Enantiomeric Resolution and Biological Evaluation of HIV Capsid Inhibition Activity for Racemic, (

Stuart Ruddell, Elena Sugrue, Sarah Memarzadeh, Lorna Mae Hellam, Sam J Wilson, David J France

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

New Synthetic Methodology for Drug-like Molecules.Molecules (Basel, Switzerland) · 2023
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Stuart RuddellSchool of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK.ORCID 0000-0001-6695-2803

Elena SugrueMRC-University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow G12 8TA, UK.ORCID 0000-0001-5014-9522

Sarah MemarzadehSchool of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK.

Lorna Mae HellamSchool of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK.

Sam J WilsonMRC-University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow G12 8TA, UK.

David J FranceSchool of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK.ORCID 0000-0002-5409-3316

Funding

Engineering and Physical Sciences Research Council EP/K503058/1Engineering and Physical Sciences Research Council EP/R513222/1Engineering and Physical Sciences Research Council EP/V008404/1

6 · The paper itself

Abstract

PF74 is a capsid-targeting inhibitor of HIV replication that effectively perturbs the highly sensitive viral uncoating process. A lack of information regarding the optical purity (enantiomeric excess) of the single stereogenic centre of PF74 has resulted in ambiguity as to the potency of different samples of this compound. Herein is described the synthesis of enantiomerically enriched (

Indexed as

Anti-HIV AgentsCapsidCapsid ProteinsChromatography, High Pressure LiquidHEK293 CellsHIV-1HIV InfectionsHumansIndolesInhibitory Concentration 50Molecular Docking SimulationPhenylalanineStereoisomerismAnti-HIV AgentsCapsid ProteinsIndolesPF-3450074Phenylalanineantiviraldockingracemizationstereochemistry

Identifiers

PMID34206893

DOI10.3390/molecules26133919

PMCPMC8272108

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.