Evidence map›Paper›PMID 34206839›Full record

ReviewViruses2021

Confound, Cause, or Cure: The Effect of Cannabinoids on HIV-Associated Neurological Sequelae.

Alexander Starr, Kelly L Jordan-Sciutto, Eugene Mironets

Open access · goldAbstract readReview
In one paragraph

Review in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Alexander StarrDepartment of Basic and Translational Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
Kelly L Jordan-SciuttoDepartment of Basic and Translational Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
Eugene MironetsDepartment of Basic and Translational Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
University of Pennsylvania · US

Funding

PREDOCTORAL TRAINING PROGRAM IN PHARMACOLOGYT32GM008076 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BLENDY, JULIE A · 1985 to 2023
$10.8M
SYSTEMS AND INTEGRATIVE BIOLOGYT32GM007517 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI GOLD, JOSHUA I · 1985 to 2017
$8.0M
BRIAN INJURY TRAINING GRANTT32NS043126 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Douglas Hamilton Smith · 2003 to 2026
$5.9M
Inter- and Intra-cellular effects of cannabinoids, HIV and ART in the CNSR01DA052826 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI JORDAN-SCIUTTO, KELLY L · 2021 to 2025
$3.5M
Modeling CNS dynamics in HIV infection and cannabinoids with forebrain organoidsR01DA049514 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI CHRISTIAN, KIMBERLY, JORDAN-SCIUTTO, KELLY L · 2019 to 2023
$3.5M
Cannabinoid Modulation of Neuroinflammation in Human iPSC Models of HIV InfectionF31DA054001 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI STARR, ALEXANDER · 2021 to 2023
$126k
NIDA NIH HHS F31 DA054001NIDA NIH HHS R01 DA049514NIDA NIH HHS R01DA049514NIDA NIH HHS R01 DA052826NIGMS NIH HHS T32 GM007517NIGMS NIH HHS T32GM008076NINDS NIH HHS 5T32NS043126NINDS NIH HHS T32 NS043126
6 · The paper itself

Abstract

The persistence of human immunodeficiency virus-1 (HIV)-associated neurocognitive disorders (HAND) in the era of effective antiretroviral therapy suggests that modern HIV neuropathogenesis is driven, at least in part, by mechanisms distinct from the viral life cycle. Identifying more subtle mechanisms is complicated by frequent comorbidities in HIV

Indexed as

AnimalsAnti-HIV AgentsCannabinoidsClinical Trials as TopicDrug Evaluation, PreclinicalHIV-1HIV InfectionsHumansIn Vitro TechniquesMiceNeuroinflammatory DiseasesPsychotropic DrugsAnti-HIV AgentsCannabinoidsPsychotropic DrugsantiretroviralcannabinoidsCB1CB2HANDHIV

Identifiers

PMID34206839
PMCPMC8310358
OpenAlexW3173959369

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.