Evidence map›Paper›PMID 34206763›Full record

ArticleInternational journal of molecular sciences2021

Betulinic Acid Ameliorates the Severity of Acute Pancreatitis via Inhibition of the NF-κB Signaling Pathway in Mice.

Ziqi Zhou, Ji-Won Choi, Joon Yeon Shin, Dong-Uk Kim, Bitna Kweon, Hyuncheol Oh, Youn-Chul Kim, Ho-Joon Song, Gi-Sang Bae, Sung-Joo Park

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. A Comprehensive Review of the Effects ofPreventive nutrition and food science · 2025
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  6. Obstructive Sleep Apnea-induced Endothelial Dysfunction Is Mediated by miR-210.American journal of respiratory and critical care medicine · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Ziqi ZhouDepartment of Herbology, School of Korean Medicine, Wonkwang University, 460 Iksandaero, Iksan 54538, Jeonbuk, Korea.
Ji-Won ChoiDepartment of Herbology, School of Korean Medicine, Wonkwang University, 460 Iksandaero, Iksan 54538, Jeonbuk, Korea.
Joon Yeon ShinDepartment of Herbology, School of Korean Medicine, Wonkwang University, 460 Iksandaero, Iksan 54538, Jeonbuk, Korea.
Dong-Uk KimHanbang Cardio-Renal Syndrome Research Center, School of Korean Medicine, Wonkwang University, 460 Iksandaero, Iksan 54538, Jeonbuk, Korea.
Bitna KweonDepartment of Herbology, School of Korean Medicine, Wonkwang University, 460 Iksandaero, Iksan 54538, Jeonbuk, Korea.
Hyuncheol OhInstitute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, 460 Iksandaero, Iksan 54538, Jeonbuk, Korea.
Youn-Chul KimInstitute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, 460 Iksandaero, Iksan 54538, Jeonbuk, Korea.
Ho-Joon SongDepartment of Herbology, School of Korean Medicine, Wonkwang University, 460 Iksandaero, Iksan 54538, Jeonbuk, Korea.
Gi-Sang BaeHanbang Cardio-Renal Syndrome Research Center, School of Korean Medicine, Wonkwang University, 460 Iksandaero, Iksan 54538, Jeonbuk, Korea.
Sung-Joo ParkDepartment of Herbology, School of Korean Medicine, Wonkwang University, 460 Iksandaero, Iksan 54538, Jeonbuk, Korea.
Wonkwang University · KR

Funding

National Research Foundation of Korea (NRF) NRF-2017R1A5A2015805National Research Foundation of Korea (NRF) NRF-2019R1A2C2008814National Research Foundation of Korea (NRF) NRF-2020R1C1011297
6 · The paper itself

Abstract

Acute pancreatitis (AP) is an inflammatory disorder, involving acinar cell death and the release of inflammatory cytokines. Currently, there are limited effective therapeutic agents for AP. Betulinic acid (BA) is a pentacyclic triterpenoid extracted from

Indexed as

AmylasesAnimalsAnti-Inflammatory AgentsBetulinic AcidCells, CulturedCytokinesFemaleLipaseLungMacrophagesMiceMice, Inbred C57BLNeutrophilsNF-kappa BPancreasPancreatitisAmylasesAnti-Inflammatory AgentsBetulinic AcidCytokinesLipaseNF-kappa BPentacyclic TriterpenesPeroxidaseacinar cellacute pancreatitisbetulinic acidinflammationnuclear factor-kappa B

Identifiers

PMID34206763
PMCPMC8268208
OpenAlexW3175733855

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.