Evidence map›Paper›PMID 34206644›Full record

ArticleJournal of clinical medicine2021

Chronic Inflammation Mediates the Association between Cortisol and Hyperglycemia: Findings from the Cross-Sectional Population-Based KORA Age Study.

Hamimatunnisa Johar, Derek Spieler, Martin Bidlingmaier, Christian Herder, Wolfgang Rathmann, Wolfgang Koenig, Annette Peters, Johannes Kruse, Karl-Heinz Ladwig

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 1 country.

Hamimatunnisa JoharDepartment of Psychosomatic Medicine and Psychotherapy, University of Gießen and Marburg, 35392 Gießen, Germany.
Derek SpielerInstitute of Epidemiology, Helmholtz Zentrum München, 85764 Neuherberg, Germany.
Martin BidlingmaierMedizinische Klinik und Poliklinik IV, Klinikum der Ludwig-Maximilians-Universität München, 80336 Munich, Germany.
Christian HerderGerman Center for Diabetes Research (DZD), München, 85764 Neuherberg, Germany.ORCID 0000-0002-2050-093X
Wolfgang RathmannDivision of Endocrinology and Diabetology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, 40225 Düsseldorf, Germany.
Wolfgang KoenigDeutsches Herzzentrum München DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, 80636 Munich, Germany.
Annette PetersGerman Center for Diabetes Research (DZD), München, 85764 Neuherberg, Germany.
Johannes KruseDepartment of Psychosomatic Medicine and Psychotherapy, University of Gießen and Marburg, 35392 Gießen, Germany.
Karl-Heinz LadwigGerman Center for Diabetes Research (DZD), München, 85764 Neuherberg, Germany.
Düsseldorf University Hospital · DEJustus-Liebig-Universität Gießen · DEHelmholtz Zentrum München · DELMU Klinikum · DETUM Klinikum · DEUniversität Ulm · DEUniversity of Freiburg · DE

Funding

Bundesministerium für Bildung und Forschung BMBF FKZ 01ET0713
6 · The paper itself

Abstract

(1) Background: The study aimed to investigate the role of subclinical inflammation on the association between diurnal cortisol patterns and glycaemia in an aged population. (2) Methods: Salivary cortisol, interleukin-6 (IL-6) and glycated haemoglobin (HbA1c) were analysed in a sample of 394 men and 364 women (mean age = 5 ± 6.3, 65-90 years). The ratio of morning after awakening and late-night cortisol was calculated as an indication of diurnal cortisol slope (DCS). Multivariable regression models were run to examine whether IL-6 mediates the relationship between the DCS and glycaemia. The Sobel test and bootstrapping methods were used to quantify the mediation analyses. (3) Results: In comparison to normoglycaemic counterparts (

Indexed as

cortisolHbA1cinterleukin-6mediation analysispsychological stress

Identifiers

PMID34206644
PMCPMC8267679
OpenAlexW3176836625

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.