ArticleJournal of clinical medicine2021
Diagnosis of Subclinical Keratoconus with a Combined Model of Biomechanical and Topographic Parameters.
Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Photorefractive keratectomy in patients with thin corneas: systematic review and meta-analysis of clinical outcomes and complications.Journal of cataract and refractive surgery · 2026Pooled it
- Enhancing the diagnostic precision of subclinical keratoconus by combining indices from Scheimpflug tomography, corneal biomechanics, and anterior segment optical coherence tomography.International journal of ophthalmology · 2026Article
- Strategies for Early Keratoconus Diagnosis: A Narrative Review of Evaluating Affordable and Effective Detection Techniques.Journal of clinical medicine · 2025Review
- Diagnostic value of corneal optical densitometry in keratoconus.International ophthalmology · 2024Article
- Corneal biomechanics in early diagnosis of keratoconus using artificial intelligence.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Review
- Corneal biomechanics in normal and subclinical keratoconus eyes.BMC ophthalmology · 2023Article
- Corneal biomechanical properties in vernal keratoconjunctivitis and its subtypes: a preliminary study.International ophthalmology · 2023Article
- Detection ability of corneal biomechanical parameters for early diagnosis of ectasia.Eye (London, England) · 2023Article
- Artificial Intelligence for Anterior Segment Diseases: A Review of Potential Developments and Clinical Applications.Ophthalmology and therapy · 2023Review
- Analysis of the diagnostic accuracy of Belin/Ambrósio Enhanced Ectasia and Corvis ST parameters for subclinical keratoconus.International ophthalmology · 2023Article
- Comprehensive Assessment of Corvis ST Biomechanical Indices in Normal and Keratoconus Corneas with Reference to Corneal Enantiomorphism.Journal of clinical medicine · 2023Article
- Diagnosis of Subclinical Keratoconus Based on Machine Learning Techniques.Journal of clinical medicine · 2021Article
- Clinical Applications of Artificial Intelligence in Glaucoma.Journal of ophthalmic & vision researchReview
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
This study sought to develop a diagnostic model with aberrometry and biomechanical variables for subclinical keratoconus. The design was a cross-sectional study. The topographic data were obtained with a rotating Scheimpflug camera (Pentacam HR), and biomechanical data were obtained with Corvis ST. The study included 81 eyes distributed in 61 healthy corneas and 20 subclinical keratoconus (SCKC), defined as eyes with suspicious topographic findings, normal slit-lamp examination, and a manifestation of keratoconus. Analyses of the topographic and biomechanical data were performed, and a classifying model of SCKC was elaborated. The model for the diagnosis of SCKC includes posterior coma to 90°, Ambrósio's Relational Thickness in the horizontal profile (ARTh), and velocity when the air pulse is off (A2 velocity). The sensitivity was 89.5%, specificity 96.7%, accuracy 94.9%, and precision 89.5%. The area under the curve (AUC) of the receiver operating characteristic (ROC) curve for the model was 0.951. Diagnosis of subclinical keratoconus depends on the aberrometry variable posterior coma to 90° and the biomechanical variables A2 velocity and ARTh.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.