Evidence map›Paper›PMID 34206507›Full record

ReviewPathogens (Basel, Switzerland)2021

A Summary of the SARS-CoV-2 Vaccines and Technologies Available or under Development.

Zainalabideen A Abdulla, Sharaf M Al-Bashir, Noor S Al-Salih, Ala A Aldamen, Mohammad Z Abdulazeez

Open access · goldAbstract readReview
In one paragraph

Review in Pathogens (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 2 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.

  1. Pooled it
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  8. A perspective on SARS-CoV-2 virus-like particles vaccines.International immunopharmacology · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Zainalabideen A AbdullaDepartment of Clinical Sciences, Faculty of Medicine, Yarmouk University, Irbid 21163, Jordan.
Sharaf M Al-BashirDepartment of Clinical Sciences, Faculty of Medicine, Yarmouk University, Irbid 21163, Jordan.
Noor S Al-SalihDepartment of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid 21163, Jordan.
Ala A AldamenDepartment of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid 21163, Jordan.
Mohammad Z AbdulazeezInternship Program, Princess Basma Teaching Hospital, Irbid 26125, Jordan.
Yarmouk University · JOMédecins Sans Frontières · JO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since the beginning of 2020, the world has been in a race to develop vaccines that can control the COVID-19 pandemic. More than 250 projects have been initiated for this purpose, but only 14 of them have been authorized for use, despite being in phase 3 clinical trials. More than 40 other vaccines are also in phase 1/2 clinical trials and show promising outcomes. Regarding the appropriate choice of vaccines for each country or region, we reviewed the currently used vaccines in light of the different influencing parameters. These factors include the mode of action, dosage protocol, age group of the vaccinee, side effects, storage conditions, mounted immune response, and cost. Technically, there are seven types of vaccines developed against SARS-CoV-2: messenger RNA (mRNA), nonreplicating and replicating vectors, inactivated viruses, protein subunits, viral-like particles, DNA vaccines, and live attenuated vaccines. The mRNA type is being used for the first time in humans. Unfortunately, mutated variants of SARS-CoV-2 have started to appear worldwide, and researchers are investigating the effects of the currently used vaccines on them. There are many concerns regarding the long-term protection afforded by these vaccines and their side effects, and whether they require future modifications to be effective against the mutated variants. The development of new vaccines using more advanced technology is paramount for overcoming the difficulties in controlling the COVID-19 pandemic across the world.

Indexed as

COVID-19immune responseSARS-CoV-2vaccines

Identifiers

PMID34206507
PMCPMC8308489
OpenAlexW3177406393

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.