Evidence map›Paper›PMID 34206482›Full record

ArticleMolecules (Basel, Switzerland)2021

Ruthenacarborane and Quinoline: A Promising Combination for the Treatment of Brain Tumors.

Dijana Drača, Milan Marković, Marta Gozzi, Sanja Mijatović, Danijela Maksimović-Ivanić, Evamarie Hey-Hawkins

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Novel Ruthenacarborane-NSAID Conjugates.Molecules (Basel, Switzerland) · 2025
    Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Dijana DračaDepartment of Immunology, Institute for Biological Research "Siniša Stanković", National Institute of Republic of Serbia, University of Belgrade, Bul. Despota Stefana 142, 11060 Belgrade, Serbia.ORCID 0000-0001-8226-1623
Milan MarkovićDepartment of Immunology, Institute for Biological Research "Siniša Stanković", National Institute of Republic of Serbia, University of Belgrade, Bul. Despota Stefana 142, 11060 Belgrade, Serbia.
Marta GozziFaculty of Chemistry and Mineralogy, Institute of Inorganic Chemistry, Leipzig University, Johannisallee 29, 04103 Leipzig, Germany.
Sanja MijatovićDepartment of Immunology, Institute for Biological Research "Siniša Stanković", National Institute of Republic of Serbia, University of Belgrade, Bul. Despota Stefana 142, 11060 Belgrade, Serbia.
Danijela Maksimović-IvanićDepartment of Immunology, Institute for Biological Research "Siniša Stanković", National Institute of Republic of Serbia, University of Belgrade, Bul. Despota Stefana 142, 11060 Belgrade, Serbia.ORCID 0000-0002-8006-5079
Evamarie Hey-HawkinsFaculty of Chemistry and Mineralogy, Institute of Inorganic Chemistry, Leipzig University, Johannisallee 29, 04103 Leipzig, Germany.ORCID 0000-0003-4267-0603
University of Belgrade · RSLeipzig University · DE

Funding

DFG HE 1376/38-1Ministry of Education, Science and Technological Developement of the Republic of Serbia 451-03-68/2020-14/200007
6 · The paper itself

Abstract

Gliomas and glioblastomas are very aggressive forms of brain tumors, prone to the development of a multitude of resistance mechanisms to therapeutic treatments, including cytoprotective autophagy. In this work, we investigated the role and mechanism of action of the combination of a ruthenacarborane derivative with 8-hydroxyquinoline (

Indexed as

Antineoplastic AgentsAstrocytomaBrain NeoplasmsCoordination ComplexesQuinolinesRutheniumAnimalsAutophagic Cell DeathCell Line, TumorHumansRatsAntineoplastic AgentsCoordination ComplexesquinolineQuinolinesRutheniumautophagygliomaglucose deprivationruthenacarborane

Identifiers

PMID34206482
PMCPMC8270330
OpenAlexW3173800042

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.