Evidence map›Paper›PMID 34206464›Full record

ArticlePharmaceuticals (Basel, Switzerland)2021

Cell Death and Transcriptional Responses Induced in Larvae of the Nematode

Douglas P Jasmer, Bruce A Rosa, Makedonka Mitreva

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.9field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Douglas P JasmerDepartment of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164, USA.
Bruce A RosaDepartment of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-6820-446X
Makedonka MitrevaDepartment of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-9572-3436
James S. McDonnell Foundation · USWashington State University · USWashington University in St. Louis · US

Funding

Development of small molecule inhibitors of metabolic enzymes as broad spectrum anthelmintic drugsR01AI159450 · NIAID · WASHINGTON UNIVERSITY · PI JANETKA, JAMES W, MITREVA, MAKEDONKA · 2021 to 2025
$3.9M
EVOLUTION OF THE NEMATODE INTESTINE, A KEY HOST INTERFACER01GM097435 · NIGMS · WASHINGTON UNIVERSITY · PI MITREVA, MAKEDONKA · 2011 to 2019
$2.1M
NIAID NIH HHS R01 AI159450NIGMS NIH HHS R01 GM097435NIGMS NIH HHS R01GM097435
6 · The paper itself

Abstract

Establishing methods to investigate treatments that induce cell death in parasitic nematodes will promote experimental approaches to elucidate mechanisms and to identify prospective anthelmintics capable of inducing this outcome. Here, we extended recent progress on a method to monitor cell death and to identify small molecule inhibitors in

Indexed as

anthelminticsintestinemicroscopynematodepathologyRNA-seq

Identifiers

PMID34206464
PMCPMC8308827
OpenAlexW3176844712

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.