Evidence map›Paper›PMID 34206428›Full record

ArticleCells2021

Th17/Treg-Related Intracellular Signaling in Patients with Chronic Obstructive Pulmonary Disease: Comparison between Local and Systemic Responses.

Juliana D Lourenço, Walcy R Teodoro, Denise F Barbeiro, Ana Paula P Velosa, Larissa E F Silva, Júlia B Kohler, Alyne R Moreira, Marcelo V Aun, Isadora C da Silva, Frederico L A Fernandes and 5 more

Open access · goldAbstract readComparative Study
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Role of Regulatory T Cells in Pulmonary Ageing and COPD Development.International journal of molecular sciences · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. The role of Th17 cells: explanation of relationship between periodontitis and COPD?Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022
    Review
  11. Article
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Juliana D LourençoLaboratory of Experimental Therapeutics, Department of Clinical Medicine, School of Medicine, University of Sao Paulo, Av. Dr. Arnaldo 455-Room 1220, Sao Paulo 01246-903, Brazil.ORCID 0000-0002-9291-5237
Walcy R TeodoroRheumatology Division of the Hospital das Clinicas FMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Av. Dr. Arnaldo 455-Room 3124, Sao Paulo 01246-903, Brazil.
Denise F BarbeiroLaboratory of Clinical Emergencies, Department of Clinical Medicine, School of Medicine, University of Sao Paulo, Av. Dr. Arnaldo 455-Room 3132, Sao Paulo 01246-903, Brazil.
Ana Paula P VelosaRheumatology Division of the Hospital das Clinicas FMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Av. Dr. Arnaldo 455-Room 3124, Sao Paulo 01246-903, Brazil.
Larissa E F SilvaLaboratory of Experimental Therapeutics, Department of Clinical Medicine, School of Medicine, University of Sao Paulo, Av. Dr. Arnaldo 455-Room 1220, Sao Paulo 01246-903, Brazil.
Júlia B KohlerLaboratory of Experimental Therapeutics, Department of Clinical Medicine, School of Medicine, University of Sao Paulo, Av. Dr. Arnaldo 455-Room 1220, Sao Paulo 01246-903, Brazil.
Alyne R MoreiraLaboratory of Experimental Therapeutics, Department of Clinical Medicine, School of Medicine, University of Sao Paulo, Av. Dr. Arnaldo 455-Room 1220, Sao Paulo 01246-903, Brazil.
Marcelo V AunHost & Defense Unit, Faculdade Israelita de Ciências da Saúde Albert Einstein School of Medicine, Av. Prof. Francisco Morato 4.293, Sao Paulo 05521-200, Brazil.ORCID 0000-0001-9882-5200
Isadora C da SilvaPulmonary Division-Heart Institute of Hospital das Clinicas, School of Medicine of University of Sao Paulo, Av. Dr. Enéas Carvalho Aguiar 44, Sao Paulo 05403-000, Brazil.
Frederico L A FernandesPulmonary Division-Heart Institute of Hospital das Clinicas, School of Medicine of University of Sao Paulo, Av. Dr. Enéas Carvalho Aguiar 44, Sao Paulo 05403-000, Brazil.
Elnara M NegriLaboratory of Cellular Biology, Department of Pathology, School of Medicine, University of Sao Paulo, Av. Dr. Arnaldo 455-Room 4349, Sao Paulo 01246-903, Brazil.ORCID 0000-0002-6428-6066
Jefferson L GrossDepartment of Thoracic Surgery, A C Camargo Cancer Center, R. Prof Antonio Prudente 211, Sao Paulo 01509-010, Brazil.ORCID 0000-0001-5124-2235
Iolanda F L C TibérioLaboratory of Experimental Therapeutics, Department of Clinical Medicine, School of Medicine, University of Sao Paulo, Av. Dr. Arnaldo 455-Room 1220, Sao Paulo 01246-903, Brazil.
Juliana T ItoLaboratory of Experimental Therapeutics, Department of Clinical Medicine, School of Medicine, University of Sao Paulo, Av. Dr. Arnaldo 455-Room 1220, Sao Paulo 01246-903, Brazil.ORCID 0000-0002-9438-5292
Fernanda D T Q S LopesLaboratory of Experimental Therapeutics, Department of Clinical Medicine, School of Medicine, University of Sao Paulo, Av. Dr. Arnaldo 455-Room 1220, Sao Paulo 01246-903, Brazil.ORCID 0000-0002-6402-3055
Universidade de São Paulo · BRHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRAC Camargo Hospital · BR

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2016/21408-6 and 2016/17817-8
6 · The paper itself

Abstract

Th17/Treg imbalance plays a pivotal role in COPD development and progression. We aimed to assess Th17/Treg-related intracellular signaling at different COPD stages in local and systemic responses. Lung tissue and/or peripheral blood samples were collected and divided into non-obstructed (NOS), COPD stages I and II, and COPD stages III and IV groups. Gene expression of

Indexed as

Signal TransductionAgedCytokinesFemaleHumansIntracellular SpaceLungMaleMiddle AgedPulmonary Disease, Chronic ObstructiveTh17 CellsT-Lymphocytes, RegulatoryTranscription FactorsCytokinesTranscription FactorsCOPDintracellular signalingSTATTh17Treg

Identifiers

PMID34206428
PMCPMC8305827
OpenAlexW3174773115

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.