Evidence map›Paper›PMID 34206423›Full record

ArticleInternational journal of environmental research and public health2021

Developmental Neurotoxicity of Environmentally Relevant Pharmaceuticals and Mixtures Thereof in a Zebrafish Embryo Behavioural Test.

Alessandro Atzei, Ingrid Jense, Edwin P Zwart, Jessica Legradi, Bastiaan J Venhuis, Leo T M van der Ven, Harm J Heusinkveld, Ellen V S Hessel

Open access · goldAbstract read
In one paragraph

Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Sensory-Motor Perturbations in Larval Zebrafish (International journal of molecular sciences · 2022
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Alessandro AtzeiNational Institute for Public Health and the Environment (RIVM), 3721 AB Bilthoven, The Netherlands.ORCID 0000-0002-5638-9591
Ingrid JenseNational Institute for Public Health and the Environment (RIVM), 3721 AB Bilthoven, The Netherlands.
Edwin P ZwartNational Institute for Public Health and the Environment (RIVM), 3721 AB Bilthoven, The Netherlands.
Jessica LegradiEnvironment & Health, VU University Amsterdam, 1081 HV Amsterdam, The Netherlands.ORCID 0000-0003-0388-860X
Bastiaan J VenhuisNational Institute for Public Health and the Environment (RIVM), 3721 AB Bilthoven, The Netherlands.
Leo T M van der VenNational Institute for Public Health and the Environment (RIVM), 3721 AB Bilthoven, The Netherlands.
Harm J HeusinkveldNational Institute for Public Health and the Environment (RIVM), 3721 AB Bilthoven, The Netherlands.ORCID 0000-0002-3269-5586
Ellen V S HesselNational Institute for Public Health and the Environment (RIVM), 3721 AB Bilthoven, The Netherlands.
National Institute for Public Health and the Environment · NLVrije Universiteit Amsterdam · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Humans are exposed daily to complex mixtures of chemical substances via food intake, inhalation, and dermal contact. Developmental neurotoxicity is an understudied area and entails one of the most complex areas in toxicology. Animal studies for developmental neurotoxicity (DNT) are hardly performed in the context of regular hazard studies, as they are costly and time consuming and provide only limited information as to human relevance. There is a need for a combination of in vitro and in silico tests for the assessment of chemically induced DNT in humans. The zebrafish (

Indexed as

Neurotoxicity SyndromesPharmaceutical PreparationsWater Pollutants, ChemicalAnimalsBehavior Rating ScaleEmbryo, NonmammalianHumansZebrafishPharmaceutical PreparationsWater Pollutants, Chemicalalternative to in vivo testchemical mixturesdevelopmental neurotoxicity (DNT)environmental and human risk assessmentpsychopharmaceuticalszebrafish embryo behavioural test

Identifiers

PMID34206423
PMCPMC8297305
OpenAlexW3174444395

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.