Evidence map›Paper›PMID 34206390›Full record

ArticleBiomolecules2021

A Metalloproteinase Induces an Inflammatory Response in Preadipocytes with the Activation of COX Signalling Pathways and Participation of Endogenous Phospholipases A

Priscila Motta Janovits, Elbio Leiguez, Viviane Portas, Catarina Teixeira

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Priscila Motta JanovitsLaboratório de Farmacologia, Instituto Butantan, São Paulo 05503-900, Brazil.
Elbio LeiguezLaboratório de Farmacologia, Instituto Butantan, São Paulo 05503-900, Brazil.
Viviane PortasCentre of Excellence in New Target Discovery (CENTD), Instituto Butantan, São Paulo 05503-900, Brazil.
Catarina TeixeiraLaboratório de Farmacologia, Instituto Butantan, São Paulo 05503-900, Brazil.ORCID 0000-0001-5887-7663
Instituto Butantan · BR

Funding

Fundação de Amparo a Pesquisa do Estado de Sao Paulo 2015/50040-4
6 · The paper itself

Abstract

Matrix metalloproteinases (MMPs) are proteolytic enzymes that have been associated with the pathogenesis of inflammatory diseases and obesity. Adipose tissue in turn is an active endocrine organ capable of secreting a range of proinflammatory mediators with autocrine and paracrine properties, which contribute to the inflammation of adipose tissue and adjacent tissues. However, the potential inflammatory effects of MMPs in adipose tissue cells are still unknown. This study investigates the effects of BmooMPα-I, a single-domain snake venom metalloproteinase (SVMP), in activating an inflammatory response by 3T3-L1 preadipocytes in culture, focusing on prostaglandins (PGs), cytokines, and adipocytokines biosynthesis and mechanisms involved in prostaglandin E

Indexed as

3T3-L1 CellsAdipocytesAnimalsCrotalid VenomsDinoprostoneGroup IV Phospholipases A2InflammationMetalloendopeptidasesMiceProstaglandin-Endoperoxide SynthasesSignal TransductionBmooMP-alpha-I, Bothrops moojeniCrotalid VenomsDinoprostoneGroup IV Phospholipases A2MetalloendopeptidasesProstaglandin-Endoperoxide Synthasesadipokinescytokinesmetalloproteinasepreadipocytesprostaglandins

Identifiers

PMID34206390
PMCPMC8301905
OpenAlexW3177429904

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.