Evidence map›Paper›PMID 34206357›Full record

ArticleMolecules (Basel, Switzerland)2021

Development and Validation of a Method for Quantification of Favipiravir as COVID-19 Management in Spiked Human Plasma.

Mohammad Hailat, Israa Al-Ani, Mohammed Hamad, Zainab Zakareia, Wael Abu Dayyih

Open access · goldAbstract readValidation Study
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 49 citations in OpenAlex.

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  4. Review
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  6. Cost-effectiveness of Favipiravir in moderately to severely ill COVID-19 patients in the real-world setting of Saudi arabian pandemic referral hospitals.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023
    Article
  7. Article
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  12. Menthol-assisted homogenous liquid-liquid microextraction for HPLC/UV determination of favipiravir as an antiviral for COVID-19 in human plasma.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2022
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Mohammad HailatFaculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, Jordan.ORCID 0000-0003-4263-0134
Israa Al-AniFaculty of Pharmacy, Al-Ahliyya Amman University, Amman 19328, Jordan.
Mohammed HamadCollege of Science and Health Professions, King Saud Bin Abdulaziz University for Health Sciences, Jeddah 21423, Saudi Arabia.ORCID 0000-0001-7275-8206
Zainab ZakareiaFaculty of Pharmacy and Medical Sciences, University of Petra, Amman 11196, Jordan.
Wael Abu DayyihFaculty of Pharmacy and Medical Sciences, University of Petra, Amman 11196, Jordan.ORCID 0000-0003-2432-9356
Petra University · JOAl-Ahliyya Amman University · JOAl-Zaytoonah University of Jordan · JOKing Saud bin Abdulaziz University for Health Sciences · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the current work, a simple, economical, accurate, and precise HPLC method with UV detection was developed to quantify Favipiravir (FVIR) in spiked human plasma using acyclovir (ACVR) as an internal standard in the COVID-19 pandemic time. Both FVIR and ACVR were well separated and resolved on the C18 column using the mobile phase blend of methanol:acetonitrile:20 mM phosphate buffer (pH 3.1) in an isocratic mode flow rate of 1 mL/min with a proportion of 30:10:60 %,

Indexed as

COVID-19 Drug TreatmentAcyclovirAmidesAntiviral AgentsBiological AssayCalibrationChromatography, High Pressure LiquidCOVID-19Drug StabilityFreezingHumansLiquid-Liquid ExtractionPyrazinesReference StandardsReproducibility of ResultsSolventsAcyclovirAmidesAntiviral AgentsfavipiravirPyrazinesSolventsacyclovirbio-analyticalfavipiravirHPLCspiked human plasmavalidation

Identifiers

PMID34206357
PMCPMC8270293
OpenAlexW3176881508

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.