Evidence map›Paper›PMID 34206356›Full record

ArticleBioengineering (Basel, Switzerland)2021

A Preliminary Validation of a New Surgical Procedure for the Treatment of Primary Bladder Neck Obstruction Using a Computational Modeling Approach.

Michele Serpilli, Gianluca Zitti, Marco Dellabella, Daniele Castellani, Elvira Maranesi, Micaela Morettini, Stefano Lenci, Laura Burattini

Open access · goldAbstract read
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Michele SerpilliDepartment of Civil and Building Engineering, and Architecture, Università Politecnica delle Marche, Via Brecce Biance, 60131 Ancona, Italy.
Gianluca ZittiDepartment of Civil and Building Engineering, and Architecture, Università Politecnica delle Marche, Via Brecce Biance, 60131 Ancona, Italy.ORCID 0000-0002-4223-3772
Marco DellabellaDepartment of Urology, IRCCS INRCA, 60124 Ancona, Italy.
Daniele CastellaniDepartment of Urology, IRCCS INRCA, 60124 Ancona, Italy.ORCID 0000-0001-7354-9190
Elvira MaranesiDepartment of Urology, IRCCS INRCA, 60124 Ancona, Italy.ORCID 0000-0002-2414-3773
Micaela MorettiniDepartment of Information Engineering, Università Politecnica delle Marche, 60131 Ancona, Italy.ORCID 0000-0002-8327-8379
Stefano LenciDepartment of Civil and Building Engineering, and Architecture, Università Politecnica delle Marche, Via Brecce Biance, 60131 Ancona, Italy.ORCID 0000-0003-3154-7896
Laura BurattiniDepartment of Information Engineering, Università Politecnica delle Marche, 60131 Ancona, Italy.ORCID 0000-0002-9474-7046
Marche Polytechnic University · ITIstituti di Ricovero e Cura a Carattere Scientifico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A new surgical procedure for the treatment of primary bladder neck obstruction with maintenance of anterograde ejaculation is proposed. In place of monolateral or bilateral bladder neck incision, associated with a loss of ejaculation rate of up to 30%, the new surgical procedure consists of laser drilling the bladder neck with a number of holes and without muscle fiber disruption. The effect of this novel procedure has been studied numerically, with a simplified two-dimensional numerical model of the internal urethral sphincter, varying the position and the number of holes in the fibrotic region of the urethral tissue. Results show an improvement of the urethral sphincter opening by increasing the number of holes, ranging from about 6% to 16% of recovery. Moreover, a non-aligned position of holes positively influences the opening recovery. The concentrations of maximum principal strain and stress have been registered in the proximity of the interface between the physiologic and diseased sphincter, and in those regions where the radial thickness is significantly thinner. The effects on the first five patients have been included in the study, showing improvement in micturition, lower urinary tract symptoms, sustained ejaculatory function, and quality of life.

Indexed as

bladder neck obstructioncomputational biomechanicsejaculationtissue mechanicsurethral sphincter

Identifiers

PMID34206356
PMCPMC8301152
OpenAlexW3176498313

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.