Evidence map›Paper›PMID 34206307›Full record

ArticleCancers2021

PD-L1 Expression Associated with Epstein-Barr Virus Status and Patients' Survival in a Large Cohort of Gastric Cancer Patients in Northern Brazil.

Caroline de Fátima Aquino Moreira-Nunes, Cláudia Nazaré de Souza Almeida Titan Martins, Danielle Feio, Isamu Komatsu Lima, Leticia Martins Lamarão, Carolina Rosal Teixeira de Souza, Igor Brasil Costa, Jersey Heitor da Silva Maués, Paulo Cardoso Soares, Paulo Pimentel de Assumpção and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Advances in gastric cancer research will light the way to control this cancer.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2022
    Article
  7. Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Caroline de Fátima Aquino Moreira-NunesLaboratory of Molecular Biology, Department of Clinical Medicine, Ophir Loyola Hospital, Belém, 66063-240 PA, Brazil.ORCID 0000-0001-5845-3481
Cláudia Nazaré de Souza Almeida Titan MartinsLaboratory of Molecular Biology, Department of Clinical Medicine, Ophir Loyola Hospital, Belém, 66063-240 PA, Brazil.
Danielle FeioLaboratory of Molecular Biology, Department of Clinical Medicine, Ophir Loyola Hospital, Belém, 66063-240 PA, Brazil.
Isamu Komatsu LimaLaboratory of Molecular Biology, Department of Clinical Medicine, Ophir Loyola Hospital, Belém, 66063-240 PA, Brazil.ORCID 0000-0003-0107-9550
Leticia Martins LamarãoFoundation Center for Hemotherapy and Hematology of Pará (HEMOPA), Department of Sorology, Belém, 66033-000 PA, Brazil.
Carolina Rosal Teixeira de SouzaHuman Cytogenetics Laboratory, Biological Science Institute, Federal University of Pará, Belém, 66075-110 PA, Brazil.
Igor Brasil CostaDepartment of Virology, Evandro Chagas Institute, Ananindeua, 67030-000 PA, Brazil.ORCID 0000-0003-2600-4109
Jersey Heitor da Silva MauésHematology and Transfusion Medicine Center, Laboratory of Molecular and Cell Biology, Department of Medicine, University of Campinas, Campinas, 13083-970 SP, Brazil.
Paulo Cardoso SoaresLaboratory of Molecular Biology, Department of Clinical Medicine, Ophir Loyola Hospital, Belém, 66063-240 PA, Brazil.
Paulo Pimentel de AssumpçãoOncology Research Center, Department of Biological Sciences, Federal University of Pará, Belém, 66073-005 PA, Brazil.
Rommel Mário Rodríguez BurbanoLaboratory of Molecular Biology, Department of Clinical Medicine, Ophir Loyola Hospital, Belém, 66063-240 PA, Brazil.ORCID 0000-0002-4872-234X
Universidade Federal do Pará · BRFoundation Center · USInstituto Evandro Chagas · BRUniversidade Estadual de Campinas (UNICAMP) · BRUniversidade Federal do Ceará · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 301350/2019-1
6 · The paper itself

Abstract

Gastric cancer (GC) is a worldwide health problem, making it one of the most common types of cancer, in fifth place of all tumor types, and the third highest cause of cancer deaths in the world. There is a subgroup of GC that consists of tumors infected with the Epstein-Barr virus (EBV) and is characterized mainly by the overexpression of programmed cell death protein-ligand-1 (PD-L1). In the present study, we present histopathological and survival data of a thousand GC patients, associated with EBV status and PD-L1 expression. Of the thousand tumors analyzed, 190 were EBV-positive and the vast majority (86.8%) had a high relative expression of mRNA and PD-L1 protein (

Indexed as

biomarkerEpstein–Barr virusgastric cancerPD-L1

Identifiers

PMID34206307
PMCPMC8268941
OpenAlexW3176372344

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.