Evidence map›Paper›PMID 34206240›Full record

ArticleInternational journal of molecular sciences2021

Complex Alterations of Fatty Acid Metabolism and Phospholipidome Uncovered in Isolated Colon Cancer Epithelial Cells.

Jiřina Hofmanová, Josef Slavík, Miroslav Ciganek, Petra Ovesná, Zuzana Tylichová, Martina Karasová, Ondřej Zapletal, Nicol Straková, Jiřina Procházková, Jan Bouchal and 8 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

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  16. Fat Checking: Emerging Role of Lipids in Metabolism and Disease.International journal of molecular sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 1 country.

Jiřina HofmanováDepartment of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, 612 65 Brno, Czech Republic.
Josef SlavíkDepartment of Pharmacology and Toxicology, Veterinary Research Institute, 621 00 Brno, Czech Republic.
Miroslav CiganekDepartment of Pharmacology and Toxicology, Veterinary Research Institute, 621 00 Brno, Czech Republic.
Petra OvesnáDepartment of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, 612 65 Brno, Czech Republic.
Zuzana TylichováDepartment of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, 612 65 Brno, Czech Republic.
Martina KarasováDepartment of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, 612 65 Brno, Czech Republic.
Ondřej ZapletalDepartment of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, 612 65 Brno, Czech Republic.
Nicol StrakováDepartment of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, 612 65 Brno, Czech Republic.
Jiřina ProcházkováDepartment of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, 612 65 Brno, Czech Republic.
Jan BouchalDepartment of Clinical and Molecular Pathology, Institute of Molecular and Translational Medicine, Faculty of Medicine, Palacký University and University Hospital, 779 00 Olomouc, Czech Republic.ORCID 0000-0003-4842-1720
Zdeněk KolářDepartment of Clinical and Molecular Pathology, Institute of Molecular and Translational Medicine, Faculty of Medicine, Palacký University and University Hospital, 779 00 Olomouc, Czech Republic.
Jiří EhrmannDepartment of Surgery, University Hospital, 779 00 Olomouc, Czech Republic.
Monika LevkováDepartment of Clinical and Molecular Pathology, Institute of Molecular and Translational Medicine, Faculty of Medicine, Palacký University and University Hospital, 779 00 Olomouc, Czech Republic.
Zlatka HuškováDepartment of Clinical and Molecular Pathology, Institute of Molecular and Translational Medicine, Faculty of Medicine, Palacký University and University Hospital, 779 00 Olomouc, Czech Republic.ORCID 0000-0003-1018-8484
Pavel SkalickýDepartment of Surgery, University Hospital, 779 00 Olomouc, Czech Republic.
Alois KozubíkDepartment of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, 612 65 Brno, Czech Republic.
Miroslav MachalaDepartment of Pharmacology and Toxicology, Veterinary Research Institute, 621 00 Brno, Czech Republic.
Jan VondráčekDepartment of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, 612 65 Brno, Czech Republic.ORCID 0000-0003-4071-1969
Czech Academy of Sciences, Institute of Biophysics · CZInstitute of Molecular and Translational Medicine · CZMasaryk University · CZVeterinary Research Institute · CZUniversity Hospital Olomouc · CZ

Funding

Akademie Věd České Republiky RVO: 68081707Ministerstvo Školství, Mládeže a Tělovýchovy CZ.02.1.01/0.0/0.0/15_003/0000495Ministerstvo Školství, Mládeže a Tělovýchovy CZ.02.1.01/0.0/0.0/16_013/0001674Ministerstvo Školství, Mládeže a Tělovýchovy CZ.02.1.01/0.0/0.0/16_019/0000868Ministerstvo Zdravotnictví Ceské Republiky 15-30585AMinisterstvo Zdravotnictví Ceské Republiky DRO-FNOL00098892Ministerstvo Zemědělství RO0520
6 · The paper itself

Abstract

The development of colon cancer, one of the most common malignancies, is accompanied with numerous lipid alterations. However, analyses of whole tumor samples may not always provide an accurate description of specific changes occurring directly in tumor epithelial cells. Here, we analyzed in detail the phospholipid (PL), lysophospholipid (lysoPL), and fatty acid (FA) profiles of purified EpCAM

Indexed as

Gene Expression Regulation, NeoplasticLipid MetabolismAdenocarcinomaAgedColonic NeoplasmsEpithelial CellsFatty Acid DesaturasesFatty Acid ElongasesFatty AcidsFatty Acid SynthasesFemaleHumansLipidomicsLipogenesisMalePhospholipidsELOVL5 protein, humanFADS2 protein, humanFatty Acid DesaturasesFatty Acid ElongasesFatty AcidsFatty Acid SynthasesPhospholipidsStearoyl-CoA Desaturasecolorectal carcinomadesaturationEpCAMepithelial cellsfatty acid synthesislipidomicslysophospholipidsphospholipids

Identifiers

PMID34206240
PMCPMC8268957
OpenAlexW3175948189

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.