Evidence map›Paper›PMID 34206154›Full record

ArticleMedicines (Basel, Switzerland)2021

Thieno[2,3-

Sandra Marijan, Angela Mastelić, Anita Markotić, Nikolina Režić-Mužinić, Nikolina Vučenović, David Barker, Lisa I Pilkington, Jóhannes Reynisson, Vedrana Čikeš Čulić

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medicines (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Sandra MarijanDepartment of Medical Chemistry and Biochemistry, University of Split School of Medicine, 21000 Split, Croatia.
Angela MastelićDepartment of Medical Chemistry and Biochemistry, University of Split School of Medicine, 21000 Split, Croatia.
Anita MarkotićDepartment of Medical Chemistry and Biochemistry, University of Split School of Medicine, 21000 Split, Croatia.ORCID 0000-0002-6118-6975
Nikolina Režić-MužinićDepartment of Medical Chemistry and Biochemistry, University of Split School of Medicine, 21000 Split, Croatia.
Nikolina VučenovićDepartment of Medical Chemistry and Biochemistry, University of Split School of Medicine, 21000 Split, Croatia.
David BarkerSchool of Chemical Sciences, The University of Auckland, Auckland 1010, New Zealand.ORCID 0000-0002-3425-6552
Lisa I PilkingtonSchool of Chemical Sciences, The University of Auckland, Auckland 1010, New Zealand.ORCID 0000-0002-9292-3261
Jóhannes ReynissonSchool of Pharmacy and Bioengineering, Keele University, Staffordshire ST5 5BG, UK.ORCID 0000-0003-4174-9512
Vedrana Čikeš ČulićDepartment of Medical Chemistry and Biochemistry, University of Split School of Medicine, 21000 Split, Croatia.ORCID 0000-0002-4415-4410
University of Split · HRUniversity of Auckland · NZKeele University · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The adhesion of cancer cells to vascular endothelium is a critical process in hematogenous metastasis and might be similar to the recruitment of leukocytes at the site of inflammation. It is mediated by E-selectin and its ligands, of which the most stereospecific is a glycoconjugate sialyl Lewis x (CD15s), which may be expressed as an oligosaccharide branch of the CD44 glycoprotein, as well as a self-contained glycosphingolipid. It is also known that increased sialylation of glycoconjugates is a feature of malignant cells. The aim of the study was to analyse the effect of a novel thieno[2,3-

Indexed as

CD15s glycoproteinCD15s glycosphingolipidCD24CD44thieno[2,3-b]pyridinetriple-negative breast cancer

Identifiers

PMID34206154
PMCPMC8304450
OpenAlexW3177112761

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.