Evidence map›Paper›PMID 34206106›Full record

ArticlePharmaceutics2021

Nanoparticle-Mediated Angiotensin-(1-9) Drug Delivery for the Treatment of Cardiac Hypertrophy.

Sabrina Sepúlveda-Rivas, Matías S Leal, Zully Pedrozo, Marcelo J Kogan, María Paz Ocaranza, Javier O Morales

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Sabrina Sepúlveda-RivasMedical Technology School, Faculty of Sciences, Universidad Mayor, Camino la Piramide 5750, Huechuraba, Santiago 8580745, Chile.
Matías S LealCenter for Bioinformatics and Integrative Biology, Facultad de Ciencias de la Vida, Universidad Andrés Bello, Santiago 8370146, Chile.
Zully PedrozoRed Para el Estudio de Enfermedades Cardiopulmonares de Alta Letalidad (REECPAL), Santiago 8380453, Chile.
Marcelo J KoganAdvanced Center for Chronic Diseases (ACCDiS), Universidad de Chile & Pontificia Universidad Católica de Chile, Santiago 8380494, Chile.ORCID 0000-0003-0608-5087
María Paz OcaranzaAdvanced Center for Chronic Diseases (ACCDiS), Universidad de Chile & Pontificia Universidad Católica de Chile, Santiago 8380494, Chile.
Javier O MoralesAdvanced Center for Chronic Diseases (ACCDiS), Universidad de Chile & Pontificia Universidad Católica de Chile, Santiago 8380494, Chile.ORCID 0000-0002-3190-2168
Pontificia Universidad Católica de Chile · CLUniversidad Andrés Bello · CLUniversidad Mayor · CL

Funding

Agencia Nacional de Investigación y Desarrollo FONDAP 15130011Agencia Nacional de Investigación y Desarrollo FONDECYT Regular 1181689Agencia Nacional de Investigación y Desarrollo National Doctoral Scholarship N°21130766Agencia Nacional de Investigación y Desarrollo National Doctoral Scholarship N°21141219Agencia Nacional de Investigación y Desarrollo PIA ACT192144Pontificia Universidad Católica de Chile Puente 033/2020
6 · The paper itself

Abstract

Ang-(1-9) peptide is a bioactive vasodilator peptide that prevents cardiomyocyte hypertrophy in vitro and in vivo as well as lowers blood pressure and pathological cardiovascular remodeling; however, it has a reduced half-life in circulation, requiring a suitable carrier for its delivery. In this work, hybrid nanoparticles composed of polymeric nanoparticles (pNPs) based on Eudragit

Indexed as

angiotensin-(1-9)cardiac hypertrophygold nanoparticlespeptide deliverypolymeric nanoparticles

Identifiers

PMID34206106
PMCPMC8228229
OpenAlexW3169610939

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.