Evidence map›Paper›PMID 34206082›Full record

ArticleCancers2021

Analysis of Relationships between Immune Checkpoint and Methylase Gene Polymorphisms and Outcomes after Unrelated Bone Marrow Transplantation.

Hidekazu Takahashi, Naoko Okayama, Natsu Yamaguchi, Moe Nomura, Yuta Miyahara, M H Mahbub, Ryosuke Hase, Yasuo Morishima, Yutaka Suehiro, Takahiro Yamasaki and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Relationship Between anJournal of clinical medicine · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Hidekazu TakahashiDepartment of Public Health and Preventive Medicine, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Japan.
Naoko OkayamaDivision of Laboratory, Yamaguchi University Hospital, Ube 755-8505, Japan.
Natsu YamaguchiDepartment of Public Health and Preventive Medicine, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Japan.
Moe NomuraDepartment of Public Health and Preventive Medicine, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Japan.
Yuta MiyaharaDivision of Laboratory, Yamaguchi University Hospital, Ube 755-8505, Japan.
M H MahbubDepartment of Public Health and Preventive Medicine, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Japan.ORCID 0000-0002-1599-6256
Ryosuke HaseDepartment of Public Health and Preventive Medicine, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Japan.
Yasuo MorishimaDivision of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan.
Yutaka SuehiroDepartment of Oncology and Laboratory Medicine, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Japan.
Takahiro YamasakiDivision of Laboratory, Yamaguchi University Hospital, Ube 755-8505, Japan.ORCID 0000-0002-9793-0399
Koji TamadaDepartment of Immunology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Japan.
Satoshi TakahashiDepartment of Hematology and Oncology, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.
Arinobu TojoTokyo Medical and Dental University, Tokyo 113-8510, Japan.
Tsuyoshi TanabeDepartment of Public Health and Preventive Medicine, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Japan.
Yamaguchi University · JPYamaguchi University Hospital · JPAichi Cancer Center · JPThe University of Tokyo · JPTokyo Medical and Dental University · JP

Funding

Japan Society for the Promotion of Science KAKENHI 26460802 and 17K09158Yamaguchi Prefecture Government The R & D Promotion Subsidy System
6 · The paper itself

Abstract

Unrelated bone marrow transplantation (uBMT) is performed to treat blood disorders, and it uses bone marrow from an unrelated donor as the transplant source. Although the importance of HLA matching in uBMT has been established, that of other genetic factors, such as single-nucleotide polymorphisms (SNPs), remains unclear. The application of immunoinhibitory receptors as anticancer drugs has recently been attracting attention. This prompted us to examine the importance of immunoinhibitory receptor SNPs in uBMT. We retrospectively genotyped five single-nucleotide polymorphisms (SNPs) in the immune checkpoint genes,

Indexed as

DNA methyltransferasehistone methyltransferaseimmunoinhibitory receptorsingle-nucleotide polymorphismunrelated bone marrow transplantation

Identifiers

PMID34206082
PMCPMC8199545
OpenAlexW3170523292

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.