Evidence map›Paper›PMID 34206070›Full record

ArticleBiomolecules2021

Parallel and Sequential Pathways of Molecular Recognition of a Tandem-Repeat Protein and Its Intrinsically Disordered Binding Partner.

Ben M Smith, Pamela J E Rowling, Christopher M Dobson, Laura S Itzhaki

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Diffusion of a disordered protein on its folded ligand.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ben M SmithDepartment of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK.
Pamela J E RowlingDepartment of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK.
Christopher M DobsonDepartment of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
Laura S ItzhakiDepartment of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK.ORCID 0000-0001-6504-2576
University of Cambridge · GB

Funding

Cancer Research UK 27225Cancer Research UK C17838/A22676Cancer Research UK C17838/A27225
6 · The paper itself

Abstract

The Wnt signalling pathway plays an important role in cell proliferation, differentiation, and fate decisions in embryonic development and the maintenance of adult tissues. The twelve armadillo (ARM) repeat-containing protein β-catenin acts as the signal transducer in this pathway. Here, we investigated the interaction between β-catenin and the intrinsically disordered transcription factor TCF7L2, comprising a very long nanomolar-affinity interface of approximately 4800 Å

Indexed as

beta CateninCrystallography, X-RayHumansIntrinsically Disordered ProteinsMutagenesis, Site-DirectedProtein Structure, QuaternaryTranscription Factor 7-Like 2 Proteinbeta CateninCTNNB1 protein, humanIntrinsically Disordered ProteinsTCF7L2 protein, humanTranscription Factor 7-Like 2 Proteinarmadillo repeatbeta-cateninfuzzy complexintrinsically disordered proteinintrinsic disorderprotein foldingprotein-protein interactionsrepeat proteintandem-repeat proteinTCF

Identifiers

PMID34206070
PMCPMC8228192
OpenAlexW3168883166

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.