Evidence map›Paper›PMID 34206047›Full record

ReviewCells2021

TCL1A, B Cell Regulation and Tolerance in Renal Transplantation.

François Brinas, Richard Danger, Sophie Brouard

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03652402 (The EUropean TRAnsplantation and INnovation Consortium for Risk Stratification in Kidney Transplant Patients), which is not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03652402 completednot on this map

The EUropean TRAnsplantation and INnovation Consortium for Risk Stratification in Kidney Transplant Patients

TypeobservationalSponsorAssistance Publique - Hôpitaux de ParisRan2018 to 2021Enrolled558ConditionsKidney Transplant Rejection, Kidney Transplantation, Risk Stratification, PrognosisArmskidney transplantation
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Integrated multiomic analyses: An approach to improve understanding of diabetic kidney disease.Diabetic medicine : a journal of the British Diabetic Association · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Multi-omics profiling identifies C1QA/BAnnals of translational medicine · 2022
    Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

François BrinasUniversité de Nantes, CHU Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie, UMR 1064, ITUN, F-44000 Nantes, France.
Richard DangerUniversité de Nantes, CHU Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie, UMR 1064, ITUN, F-44000 Nantes, France.
Sophie BrouardUniversité de Nantes, CHU Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie, UMR 1064, ITUN, F-44000 Nantes, France.
Inserm · FRCenter for Research in Transplantation and Translational Immunology

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite much progress in the management of kidney transplantation, the need for life-long immunosuppressive therapies remains a major issue representing many risks for patients. Operational tolerance, defined as allograft acceptance without immunosuppression, has logically been subject to many investigations with the aim of a better understanding of post-transplantation mechanisms and potentially how it would be induced in patients. Among proposed biomarkers,

Indexed as

Kidney TransplantationTransplantation ToleranceB-LymphocytesCell DifferentiationHumansInterleukin-10Proto-Oncogene ProteinsProto-Oncogene Proteins c-aktT-LymphocytesIL10 protein, humanInterleukin-10Proto-Oncogene ProteinsProto-Oncogene Proteins c-aktTCL1A protein, humanAktBregIL-10kidney transplantationTCL1Atolerance

Identifiers

PMID34206047
PMCPMC8230170
OpenAlexW3171357024

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.