Evidence map›Paper›PMID 34205893›Full record

ArticleAnimals : an open access journal from MDPI2021

SARS-Cov-2 Natural Infection in a Symptomatic Cat: Diagnostic, Clinical and Medical Management in a One Health Vision.

Alda Natale, Elisa Mazzotta, Nicoletta Mason, Letizia Ceglie, Monica Mion, Annalisa Stefani, Alice Fincato, Francesco Bonfante, Alessio Bortolami, Isabella Monne and 5 more

Open access · goldAbstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Improving the ONE HEALTH approach: a lesson from SARS-CoV-2 pandemic.Journal of preventive medicine and hygiene · 2024
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. First Description of Serological Evidence for SARS-CoV-2 in Lactating Cows.Animals : an open access journal from MDPI · 2022
    Article
  13. Cats and SARS-CoV-2: A Scoping Review.Animals : an open access journal from MDPI · 2022
    Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Alda NataleIstituto Zooprofilattico Sperimentale delle Venezie, 35020 Legnaro, Italy.ORCID 0000-0003-2104-4531
Elisa MazzottaIstituto Zooprofilattico Sperimentale delle Venezie, 35020 Legnaro, Italy.
Nicoletta MasonVeterinarian, Clinician, Marcon, 30020 Venezia, Italy.
Letizia CeglieIstituto Zooprofilattico Sperimentale delle Venezie, 35020 Legnaro, Italy.
Monica MionIstituto Zooprofilattico Sperimentale delle Venezie, 35020 Legnaro, Italy.
Annalisa StefaniIstituto Zooprofilattico Sperimentale delle Venezie, 35020 Legnaro, Italy.ORCID 0000-0002-8071-0285
Alice FincatoIstituto Zooprofilattico Sperimentale delle Venezie, 35020 Legnaro, Italy.
Francesco BonfanteIstituto Zooprofilattico Sperimentale delle Venezie, 35020 Legnaro, Italy.
Alessio BortolamiIstituto Zooprofilattico Sperimentale delle Venezie, 35020 Legnaro, Italy.
Isabella MonneIstituto Zooprofilattico Sperimentale delle Venezie, 35020 Legnaro, Italy.
Laura BellinatiIstituto Zooprofilattico Sperimentale delle Venezie, 35020 Legnaro, Italy.ORCID 0000-0001-7809-0331
Carmine GuadagnoULSS 3 Serenissima, 30135 Venezia, Italy.
Erika QuarantaIstituto Zooprofilattico Sperimentale delle Venezie, 35020 Legnaro, Italy.
Ambra PastoriIstituto Zooprofilattico Sperimentale delle Venezie, 35020 Legnaro, Italy.
Calogero TerreginoIstituto Zooprofilattico Sperimentale delle Venezie, 35020 Legnaro, Italy.
Istituto Zooprofilattico Sperimentale delle Venezie · ITLibera Università Maria SS. Assunta · ITUniversity of Padua · ITVeterinary Oncological Center · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the reported increase in SARS-CoV-2-infected pets, the description of the clinical features from natural infection and the medical follow up in symptomatic pets is still not sufficiently documented. This study reports the case of an indoor cat that displayed respiratory signs and a gastrointestinal syndrome, following the COVID-19 diagnosis of his owners. Thoracic radiographies were suggestive of bronchial pneumonia, while blood tests were indicative of a mild inflammatory process. Nasal and oropharyngeal swabs tested positive through RT-qPCR assays targeting SARS-CoV-2 genes 14 days after his owners tested positive for the virus. Nasal swabs persisted to be RT-qPCR positive after 31 days. Serology confirmed the presence of antibodies through ELISA, electrochemiluminescence analysis and plaque reduction neutralization test, recording a high antibody titre after 31 days. The cat improved after medical treatment and clinically recovered. This study suggests that exposure to SARS-CoV-2 could lead to a natural infection with bronchial pneumonia in cats along with a possible prolonged persistence of SARS-CoV-2 RNA in the upper airways, albeit at a low level. The cat developed neutralizing antibodies, reaching a high titre after 31 days. Further descriptions of SARS-CoV-2 naturally infected pets, their medical management and diagnostic findings would be useful to enhance knowledge about COVID-19 in susceptible animals.

Indexed as

catmedical features and managementRT-qPCR molecular detectionSARS-CoV-2serologyviral genome sequencing

Identifiers

PMID34205893
PMCPMC8227534
OpenAlexW3166274899

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.