Evidence map›Paper›PMID 34205840›Full record

ArticleJournal of clinical medicine2021

Effect of Intermittent Theta Burst Stimulation on the Neural Processing of Emotional Stimuli in Healthy Volunteers.

Virginie Moulier, Christian Gaudeau-Bosma, Fanny Thomas, Clémence Isaac, Maxence Thomas, Florence Durand, Palmyre Schenin-King Andrianisaina, Romain Valabregue, Charles Laidi, René Benadhira and 2 more

Abstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Virginie MoulierUnité de Recherche Clinique, EPS Ville-Evrard, 93332 Neuilly-sur-Marne, France.
Christian Gaudeau-BosmaEspace Territoriale d'Accompagnement Psychosociale, CH Les Murets, GHT94, 94120 Fontenay sous Bois, France.
Fanny ThomasUnité de Recherche Clinique, EPS Ville-Evrard, 93332 Neuilly-sur-Marne, France.
Clémence IsaacUnité de Recherche Clinique, EPS Ville-Evrard, 93332 Neuilly-sur-Marne, France.ORCID 0000-0002-9229-0249
Maxence ThomasUnité de Recherche Clinique, EPS Ville-Evrard, 93332 Neuilly-sur-Marne, France.
Florence DurandUnité de Recherche Clinique, EPS Ville-Evrard, 93332 Neuilly-sur-Marne, France.
Palmyre Schenin-King AndrianisainaUnité de Recherche Clinique, EPS Ville-Evrard, 93332 Neuilly-sur-Marne, France.
Romain ValabregueInstitut du Cerveau et de la Moelle Épinière-ICM, Sorbonne Universités, UPMC Univ Paris 06, Inserm U1127, CNRS UMR 7225, 75013 Paris, France.
Charles LaidiPôle de Psychiatrie, Assistance Publique-Hôpitaux de Paris (AP-HP), Faculté de Médecine de Créteil, DMU IMPACT, Hôpitaux Universitaires Mondor, 94028 Créteil, France.
René BenadhiraUnité de Recherche Clinique, EPS Ville-Evrard, 93332 Neuilly-sur-Marne, France.
Noomane BouazizUnité de Recherche Clinique, EPS Ville-Evrard, 93332 Neuilly-sur-Marne, France.ORCID 0000-0003-1009-4891
Dominique JanuelUnité de Recherche Clinique, EPS Ville-Evrard, 93332 Neuilly-sur-Marne, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntermittent theta burst stimulation (iTBS) is a form of repetitive transcranial magnetic stimulation that has shown to be effective in treatment-resistant depression. Through studying the effect of iTBS on healthy subjects, we wished to attain a greater understanding of its impact on the brain. Our objective was to assess whether 10 iTBS sessions altered the neural processing of emotional stimuli, mood and brain anatomy in healthy subjects.

methodsIn this double-blind randomized sham-controlled study, 30 subjects received either active iTBS treatment (10 sessions, two sessions a day) or sham treatment over the left dorsolateral prefrontal cortex. Assessments of mood, structural magnetic resonance imaging (MRI) and functional MRI (fMRI) were performed before and after iTBS sessions. During the fMRI, three different categories of stimuli were presented: positive, negative and neutral photographs.

resultsThis study showed that, during the presentation of negative stimuli (compared with neutral stimuli), 10 sessions of iTBS increased activity in the left anterior insula. However, iTBS did not induce any change in mood, regional gray matter volume or cortical thickness.

conclusionsiTBS modifies healthy subjects' brain activity in a key region that processes emotional stimuli. (AFSSAPS: ID-RCB 2010A01032-37).

Indexed as

brainemotionhealthy subjectsiTBSrTMS

Identifiers

PMID34205840
PMCPMC8198492

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.