Evidence map›Paper›PMID 34205820›Full record

ArticleAnimals : an open access journal from MDPI2021

Expression of Transforming Growth Factor Beta Isoforms in Canine Endometrium with Cystic Endometrial Hyperplasia-Pyometra Complex.

Marta Rybska, Magdalena Woźna-Wysocka, Barbara Wąsowska, Marek Skrzypski, Magdalena Kubiak, Beata Błaszak, Anna Łukomska, Tomasz Nowak, Jędrzej M Jaśkowski

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animals : an open access journal from MDPI, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Marta RybskaDepartment of Preclinical Sciences and Infectious Diseases, Poznan University of Life Science, Wołyńska 35, 60-637 Poznan, Poland.ORCID 0000-0002-4563-3798
Magdalena Woźna-WysockaDepartment of Medical Biotechnology, Institute of Bioorganic Chemistry Polish Academy of Sciences, Noskowskiego 12/14, 61-704 Poznan, Poland.ORCID 0000-0003-2993-7000
Barbara WąsowskaDepartment of Preclinical Sciences and Infectious Diseases, Poznan University of Life Science, Wołyńska 35, 60-637 Poznan, Poland.
Marek SkrzypskiDepartment of Animal Physiology, Biochemistry and Biostructure, Poznan University of Life Sciences, Wołyńska 35, 60-637 Poznan, Poland.ORCID 0000-0003-4059-1362
Magdalena KubiakDepartment of Internal Diseases and Diagnostics, Poznan University of Life Sciences, Wołyńska 35, 60-637 Poznan, Poland.
Beata BłaszakDepartment of Tumour Pathology, Greater Poland Cancer Centre, Garbary 15, 61-866 Poznan, Poland.
Anna ŁukomskaDepartment of Preclinical Sciences and Infectious Diseases, Poznan University of Life Science, Wołyńska 35, 60-637 Poznan, Poland.ORCID 0000-0001-5046-7416
Tomasz NowakDepartment of Genetics and Animal Breeding, Poznan University of Life Sciences, Wołyńska 35, 60-637 Poznan, Poland.
Jędrzej M JaśkowskiDepartment of Diagnostics and Clinical Sciences, Institute of Veterinary Medicine, Nicolaus Copernicus University, Gagarina 7, 87-100 Torun, Poland.
University of Life Sciences in Poznań · PLGreater Poland Cancer Center · PLInLife Institute of Animal Reproduction and Food Research, Polish Academy of Sciences · PLInstitute of Bioorganic Chemistry, Polish Academy of Sciences · PLNicolaus Copernicus University · PL

Funding

Ministry of Science and Higher Education programme as "Regional Initiative Excellence" 2019-2022 005/RID/2018/19National Science Centre of Poland 2013/09/N/NZ5/01835
6 · The paper itself

Abstract

Cystic endometrial hyperplasia (CEH) and pyometra are the most frequently diagnosed uterine diseases affecting bitches of different ages. Transforming growth factor beta (TGF-β) has been classified in females as a potential regulator of many endometrial changes during the estrous cycle or may be involved in pathological disorders. The aim of this study was to determine the expression of TGF-β1, -β2 and -β3 in the endometrium of bitches suffering from CEH or a CEH-pyometra complex compared to clinically healthy females (control group; CG). A significantly increased level of TGF-β1 mRNA expression was observed in the endometrium with CEH-pyometra compared to CEH and CG. Protein production of TGF-β1 was identified only in the endometrium of bitches with CEH-pyometra. An increase in TGF-β3 mRNA expression was observed in all the studied groups compared to CG. The expression of TGF-β2 mRNA was significantly higher in CEH and lower in CEH-pyometra uteri. The results indicate the presence of TGF-β cytokines in canine endometrial tissues affected by proliferative and degenerative changes. However, among all TGF-β isoforms, TGF-β1 could potentially be a key factor involved in the regulation of the endometrium in bitches with CEH-pyometra complex.

Indexed as

caninecystic endometrial hyperplasiaendometriumpyometratransforming growth factor betauterus

Identifiers

PMID34205820
PMCPMC8234116
OpenAlexW3174253943

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.