Evidence map›Paper›PMID 34205789›Full record

ArticleCells2021

Eritoran Attenuates Hepatic Inflammation and Fibrosis in Mice with Chronic Liver Injury.

Yun-Cheng Hsieh, Kuei-Chuan Lee, Pei-Shan Wu, Teh-Ia Huo, Yi-Hsiang Huang, Ming-Chih Hou, Han-Chieh Lin

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yun-Cheng HsiehDivision of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei 11217, Taiwan.
Kuei-Chuan LeeDivision of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei 11217, Taiwan.
Pei-Shan WuDivision of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei 11217, Taiwan.
Teh-Ia HuoDivision of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei 11217, Taiwan.
Yi-Hsiang HuangDivision of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei 11217, Taiwan.ORCID 0000-0001-5241-5425
Ming-Chih HouDivision of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei 11217, Taiwan.
Han-Chieh LinDivision of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei 11217, Taiwan.
National Yang Ming Chiao Tung University · TW

Funding

National Science Council MOST 106-2314-B-075-071-MY2National Science Council MOST 108-2314-B-075-021National Science Council MOST 108-2628-B-075-008National Science Council MOST 109-2314-B-075-021National Science Council MOST 109-2628-B-075 -016
6 · The paper itself

Abstract

Toll-like receptor 4 (TLR4) signaling plays a key role in liver inflammation and fibrosis. The therapeutic effects of eritoran, a TLR4 antagonist, in mice with chronic liver injury remained unclear. C57BL/6 mice were fed a fast-food diet (FFD) or treated with carbon tetrachloride (CCl

Indexed as

Carbon Tetrachloride PoisoningEnd Stage Liver DiseaseLiver CirrhosisAnimalsDisaccharidesHepatic Stellate CellsInflammationKupffer CellsMaleMAP Kinase Signaling SystemMiceSugar PhosphatesTranscription Factor RelATransforming Growth Factor beta1DisaccharideseritoranRela protein, mouseSugar PhosphatesTgfb1 protein, mouseTranscription Factor RelATransforming Growth Factor beta1animal modelchronic liver diseasehepatic stellate cellreceptor antagonisttoll-like receptor 4

Identifiers

PMID34205789
PMCPMC8235164
OpenAlexW3177247408

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.