Evidence map›Paper›PMID 34205753›Full record

ArticleInternational journal of molecular sciences2021

Preconceptional Immunization Can Modulate Offspring Intrathymic IL-17-Producing γδT Cells with Epigenetic Implications Mediated by microRNAs.

Thamires Rodrigues de-Sousa, Rodrigo Pessôa, Andrezza Nascimento, Beatriz Oliveira Fagundes, Fábio da Ressureição Sgnotto, Alberto José da Silva Duarte, Sabri Saeed Sanabani, Jefferson Russo Victor

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PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Thamires Rodrigues de-SousaLaboratory of Medical Investigation LIM-56, Division of Clinical Dermatology, Medical School, University of São Paulo, São Paulo 05403-000, Brazil.
Rodrigo PessôaLaboratory of Medical Investigation LIM-56, Division of Clinical Dermatology, Medical School, University of São Paulo, São Paulo 05403-000, Brazil.
Andrezza NascimentoLaboratory of Medical Investigation LIM-56, Division of Clinical Dermatology, Medical School, University of São Paulo, São Paulo 05403-000, Brazil.
Beatriz Oliveira FagundesLaboratory of Medical Investigation LIM-56, Division of Clinical Dermatology, Medical School, University of São Paulo, São Paulo 05403-000, Brazil.
Fábio da Ressureição SgnottoDivision of Hematology, Medical School, University of São Paulo, São Paulo 01246-000, Brazil.
Alberto José da Silva DuarteDivision of Pathology, Medical School, University of São Paulo, São Paulo 05403-000, Brazil.
Sabri Saeed SanabaniLaboratory of Medical Investigation LIM-56, Division of Clinical Dermatology, Medical School, University of São Paulo, São Paulo 05403-000, Brazil.
Jefferson Russo VictorLaboratory of Medical Investigation LIM-56, Division of Clinical Dermatology, Medical School, University of São Paulo, São Paulo 05403-000, Brazil.ORCID 0000-0001-6092-8394
Universidade de São Paulo · BR

Funding

São Paulo Research Foundation (FAPESP) #2018/05181-7 and #2018/08631-3
6 · The paper itself

Abstract

The mechanisms through which maternal immunization can modulate offspring thymic maturation of lymphocytes are not fully understood. Here, we aimed to evaluate whether maternal OVA-immunization can inhibit the maturation of IL-17-producing γδT cells in offspring thymus, and if this mechanism has epigenetic implications mediated by microRNAs (miRNAs) expression. Wild-type (WT) C57BL/6 females were immunized with OVA in Alum or Alum alone and were mated with normal WT males. Evaluating their offspring thymus at 3 or 20 days old (d.o.), we observed that maternal OVA immunization could inhibit the thymic frequency of offspring CD27- and IL-17

Indexed as

ImmunizationIntraepithelial LymphocytesMaternal ExposureAnimalsFemaleHypersensitivityInterleukin-17MiceMice, Inbred C57BLMicroRNAsThymus GlandInterleukin-17MicroRNAsgamma-delta T cellsIL-17micemicroRNAthymus

Identifiers

PMID34205753
PMCPMC8234718
OpenAlexW3174200087

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.