Evidence map›Paper›PMID 34205739›Full record

ReviewInternational journal of molecular sciences2021

Natural Phytochemicals Derived from Gymnosperms in the Prevention and Treatment of Cancers.

Tayyebeh Ghaffari, Joo-Hyun Hong, Solmaz Asnaashari, Safar Farajnia, Abbas Delazar, Hamed Hamishehkar, Ki-Hyun Kim

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Unveiling the Bioactive Efficacy ofPharmaceuticals (Basel, Switzerland) · 2024
    Article
  4. AnPathogens (Basel, Switzerland) · 2023
    Article
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tayyebeh GhaffariDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz 15731, Iran.ORCID 0000-0002-4326-0342
Joo-Hyun HongSchool of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.
Solmaz AsnaashariBiotechnology Research Center, Tabriz University of Medical Sciences, Tabriz 15731, Iran.
Safar FarajniaDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz 15731, Iran.
Abbas DelazarResearch Center for Evidence based Medicine, Tabriz University of Medical Sciences, Tabriz 15731, Iran.
Hamed HamishehkarDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz 15731, Iran.
Ki-Hyun KimSchool of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.ORCID 0000-0002-5285-9138

Funding

National Research Foundation of Korea 2019R1A5A2027340 and 2021R1A2C2007937
6 · The paper itself

Abstract

The incidence of various types of cancer is increasing globally. To reduce the critical side effects of cancer chemotherapy, naturally derived compounds have been considered for cancer treatment. Gymnosperms are a group of plants found worldwide that have traditionally been used for therapeutic applications. Paclitaxel is a commercially available anticancer drug derived from gymnosperms. Other natural compounds with anticancer activities, such as pinostrobin and pinocembrin, are extracted from pine heartwood, and pycnogenol and enzogenol from pine bark. Gymnosperms have great potential for further study for the discovery of new anticancer compounds. This review aims to provide a rational understanding and the latest developments in potential anticancer compounds derived from gymnosperms.

Indexed as

Antineoplastic Agents, PhytogenicCycadopsidaHumansNeoplasmsAntineoplastic Agents, Phytogeniccancergymnospermnatural productspaclitaxeltraditional medicine

Identifiers

PMID34205739
PMCPMC8234227

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.