Evidence map›Paper›PMID 34205699›Full record

ArticleInternational journal of molecular sciences2021

Epitranscriptomics of Ischemic Heart Disease-The IHD-EPITRAN Study Design and Objectives.

Vilbert Sikorski, Pasi Karjalainen, Daria Blokhina, Kati Oksaharju, Jahangir Khan, Shintaro Katayama, Helena Rajala, Satu Suihko, Suvi Tuohinen, Kari Teittinen and 29 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05632432 (Autologous Atrial Appendage Micrografts Transplanted During Coronary Artery Bypass Surgery), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05632432 narecruitingnot on this mapstarted 2024, after this paper: background citation

Autologous Atrial Appendage Micrografts Transplanted During Coronary Artery Bypass Surgery: the AAMS2 Randomized, Double-blinded, and Placebo-controlled Trial

TypeinterventionalSponsorHospital District of Helsinki and UusimaaRan2024 to 2026Enrolled50ConditionsIschemic Heart Disease, Ischemic Cardiomyopathy, Heart Failure, Systolic, Heart Failure NYHA Class IIIArmsEpicardial AAMs-patch transplantation, RNA-stabilized whole blood sampling, Plasma sampling, Transthoracic echocardiography, Late-gadolinium enhancement cardiac magnetic resonance imaging (LGE-CMRI)
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. RNA modification mEpigenetics · 2023
    Review
  3. Review
  4. Review
  5. Review
  6. Epitranscriptomics of cardiovascular diseases (Review).International journal of molecular medicine · 2022
    Review
  7. N6-Methyladenosine RNA Methylation in Cardiovascular Diseases.Frontiers in cardiovascular medicine · 2022
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

39 authors at 10 institutions in 4 countries.

Vilbert SikorskiDepartment of Pharmacology, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.
Pasi KarjalainenHeart and Lung Center, Helsinki University Hospital, 00029 Helsinki, Finland.
Daria BlokhinaDepartment of Pharmacology, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.
Kati OksaharjuHeart and Lung Center, Helsinki University Hospital, 00029 Helsinki, Finland.
Jahangir KhanTampere Heart Hospital, Tampere University Hospital, 33520 Tampere, Finland.
Shintaro KatayamaFolkhälsan Research Center, 00250 Helsinki, Finland.
Helena RajalaHeart and Lung Center, Helsinki University Hospital, 00029 Helsinki, Finland.
Satu SuihkoHeart and Lung Center, Helsinki University Hospital, 00029 Helsinki, Finland.
Suvi TuohinenHeart and Lung Center, Helsinki University Hospital, 00029 Helsinki, Finland.
Kari TeittinenHeart and Lung Center, Helsinki University Hospital, 00029 Helsinki, Finland.
Annu NummiHeart and Lung Center, Helsinki University Hospital, 00029 Helsinki, Finland.
Antti NykänenHeart and Lung Center, Helsinki University Hospital, 00029 Helsinki, Finland.
Arda EskinGraduate School of Informatics, Department of Health Informatics, Middle East Technical University, 06800 Ankara, Turkey.ORCID 0000-0001-9860-7561
Christoffer StarkHeart and Lung Center, Helsinki University Hospital, 00029 Helsinki, Finland.
Fausto BiancariHeart and Lung Center, Helsinki University Hospital, 00029 Helsinki, Finland.
Jan KissHeart and Lung Center, Helsinki University Hospital, 00029 Helsinki, Finland.
Jarmo SimpanenHeart and Lung Center, Helsinki University Hospital, 00029 Helsinki, Finland.
Jussi RopponenHeart and Lung Center, Helsinki University Hospital, 00029 Helsinki, Finland.
Karl LemströmHeart and Lung Center, Helsinki University Hospital, 00029 Helsinki, Finland.
Kimmo SavinainenClinical Biobank Tampere, Tampere University Hospital, 33520 Tampere, Finland.
Maciej LalowskiHelsinki Institute of Life Science (HiLIFE), Meilahti Clinical Proteomics Core Facility, Department of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, 00290 Helsinki, Finland.ORCID 0000-0002-3683-4096
Markku KaarneHeart and Lung Center, Helsinki University Hospital, 00029 Helsinki, Finland.
Mikko JormalainenHeart and Lung Center, Helsinki University Hospital, 00029 Helsinki, Finland.
Outi ElomaaFolkhälsan Research Center, 00250 Helsinki, Finland.
Pertti KoivistoChemistry Unit, Finnish Food Authority, 00790 Helsinki, Finland.
Peter RaivioHeart and Lung Center, Helsinki University Hospital, 00029 Helsinki, Finland.
Pia BäckströmHelsinki Biobank, Hospital District of Helsinki and Uusimaa, 00029 Helsinki, Finland.
Sebastian DahlbackaHeart and Lung Center, Helsinki University Hospital, 00029 Helsinki, Finland.
Simo SyrjäläHeart and Lung Center, Helsinki University Hospital, 00029 Helsinki, Finland.
Tiina VainikkaHeart and Lung Center, Helsinki University Hospital, 00029 Helsinki, Finland.
Tommi VähäsiltaHeart and Lung Center, Helsinki University Hospital, 00029 Helsinki, Finland.
Nurcan TuncbagDepartment of Chemical and Biological Engineering, College of Engineering, Koç University, 34450 Istanbul, Turkey.ORCID 0000-0002-0389-9459
Mati KarelsonInstitute of Chemistry, University of Tartu, 50411 Tartu, Estonia.
Eero MervaalaDepartment of Pharmacology, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.
Tatu JuvonenHeart and Lung Center, Helsinki University Hospital, 00029 Helsinki, Finland.
Mika LaineHeart and Lung Center, Helsinki University Hospital, 00029 Helsinki, Finland.
Jari LaurikkaTampere Heart Hospital, Tampere University Hospital, 33520 Tampere, Finland.
Antti VentoHeart and Lung Center, Helsinki University Hospital, 00029 Helsinki, Finland.
Esko KankuriDepartment of Pharmacology, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.ORCID 0000-0002-2193-8773
Helsinki University Hospital · FIUniversity of Helsinki · FITampere University Hospital · FIFolkhälsans Forskningscentrum · FIFinnish Food Authority · FIHospital District of Helsinki and Uusimaa · FIKoç University · TRMiddle East Technical University · TRUniversity of Tartu · EEUniversity of Turku · FI

Funding

Jane ja Aatos Erkon SäätiöSydäntutkimussäätiö 2020
6 · The paper itself

Abstract

Epitranscriptomic modifications in RNA can dramatically alter the way our genetic code is deciphered. Cells utilize these modifications not only to maintain physiological processes, but also to respond to extracellular cues and various stressors. Most often, adenosine residues in RNA are targeted, and result in modifications including methylation and deamination. Such modified residues as

Indexed as

Epigenesis, GeneticTranscriptomeBiomarkersCase-Control StudiesEpigenomicsHumansMyocardial IschemiaResearch DesignRNABiomarkersRNAadenosine-to-inosineA-to-Ibiomarkersepitranscriptomicsischemic heart diseasem6AN6-methyladenosineRNA modifications

Identifiers

PMID34205699
PMCPMC8235045
OpenAlexW3174425273

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.