Evidence map›Paper›PMID 34205687›Full record

ArticleViruses2021

Successful Treatment of

Claudia Ramirez-Sanchez, Francis Gonzales, Maureen Buckley, Biswajit Biswas, Matthew Henry, Michael V Deschenes, Bri'Anna Horne, Joseph Fackler, Michael J Brownstein, Robert T Schooley and 1 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
10.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.

  1. Pooled it
  2. Review
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  9. Article
  10. Article
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  12. Article
  13. Antibiotic Resistance ofPharmaceuticals (Basel, Switzerland) · 2025
    Review
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  15. Article
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  20. Antimicrobial agents and chemotherapy · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Claudia Ramirez-SanchezDepartment of Infectious Diseases and Global Public Health, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-9012-7827
Francis GonzalesDepartment of Surgery, University of California San Diego, La Jolla, CA 92093, USA.
Maureen BuckleyDepartment of Surgery, University of California San Diego, La Jolla, CA 92093, USA.
Biswajit BiswasBiological Defense Research Directorate, Naval Medical Research Center, Fort Detrick, MD 21702, USA.
Matthew HenryBiological Defense Research Directorate, Naval Medical Research Center, Fort Detrick, MD 21702, USA.
Michael V DeschenesBiological Defense Research Directorate, Naval Medical Research Center, Fort Detrick, MD 21702, USA.
Bri'Anna HorneAdaptive Phage Therapeutics, Gaithersburg, MD 20878, USA.
Joseph FacklerAdaptive Phage Therapeutics, Gaithersburg, MD 20878, USA.
Michael J BrownsteinAdaptive Phage Therapeutics, Gaithersburg, MD 20878, USA.
Robert T SchooleyDepartment of Infectious Diseases and Global Public Health, University of California San Diego, La Jolla, CA 92093, USA.
Saima AslamDepartment of Infectious Diseases and Global Public Health, University of California San Diego, La Jolla, CA 92093, USA.
University of California San Diego · USNaval Medical Research Command · USLeidos (United States) · US

Funding

RESEARCH IN INFECTIOUS DISEASEST32AI007036 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NIZET, VICTOR · 1985 to 2025
$9.2M
NIAID NIH HHS T32 AI007036
6 · The paper itself

Abstract

Successful joint replacement is a life-enhancing procedure with significant growth in the past decade. Prosthetic joint infection occurs rarely; it is a biofilm-based infection that is poorly responsive to antibiotic alone. Recent interest in bacteriophage therapy has made it possible to treat some biofilm-based infections, as well as those caused by multidrug-resistant pathogens, successfully when conventional antibiotic therapy has failed. Here, we describe the case of a 61-year-old woman who was successfully treated after a second cycle of bacteriophage therapy administered at the time of a two-stage exchange procedure for a persistent methicillin-sensitive

Indexed as

Arthritis, InfectiousBacteriophagesBiofilmsFemaleHumansMethicillin-Resistant Staphylococcus aureusMiddle AgedPhage TherapyProsthesis-Related InfectionsStaphylococcal Infectionsbacteriophagephage therapyprosthetic joint

Identifiers

PMID34205687
PMCPMC8233819
OpenAlexW3175918899

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.