Evidence map›Paper›PMID 34205607›Full record

ArticleInternational journal of molecular sciences2021

Electrophysiology of hiPSC-Cardiomyocytes Co-Cultured with HEK Cells Expressing the Inward Rectifier Channel.

Ana Da Silva Costa, Peter Mortensen, Maria P Hortigon-Vinagre, Marcel A G van der Heyden, Francis L Burton, Hao Gao, Radostin D Simitev, Godfrey L Smith

Open access · goldAbstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Environmental Cues Facilitate Maturation and Patterning of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2024
    Article
  3. Review
  4. Article
  5. hiPSC-Derived Cells as Models for Drug Discovery 2.0.International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Ana Da Silva CostaInstitute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, 126 University Place, Glasgow G12 8QQ, UK.ORCID 0000-0003-3229-5424
Peter MortensenSchool of Mathematics and Statistics, University of Glasgow, Glasgow G12 8QQ, UK.
Maria P Hortigon-VinagreDepartment of Biochemistry and Molecular Biology and Genetics, College of Sciences, University of Extremadura, 06006 Badajoz, Spain.ORCID 0000-0001-5531-1779
Marcel A G van der HeydenDepartment of Medical Physiology, Division of Heart & Lungs, University Medical Center Utrecht, Yalelaan 50, 3584 CM Utrecht, The Netherlands.ORCID 0000-0002-4225-7942
Francis L BurtonInstitute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, 126 University Place, Glasgow G12 8QQ, UK.
Hao GaoSchool of Mathematics and Statistics, University of Glasgow, Glasgow G12 8QQ, UK.
Radostin D SimitevSchool of Mathematics and Statistics, University of Glasgow, Glasgow G12 8QQ, UK.ORCID 0000-0002-2207-5789
Godfrey L SmithInstitute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, 126 University Place, Glasgow G12 8QQ, UK.
University of Glasgow · GBUniversidad de Extremadura · ESUniversity Medical Center Utrecht · NL

Funding

Engineering and Physical Sciences Research Council EP/N014642/1, EP/S030875/1, EP/T017899/1, EP/2053958
6 · The paper itself

Abstract

The immature electrophysiology of human-induced pluripotent stem cell-derived cardiomyocytes (hiCMs) complicates their use for therapeutic and pharmacological purposes. An insufficient inward rectifying current (I

Indexed as

Coculture TechniquesGiant CellsHEK293 CellsHumansInduced Pluripotent Stem CellsMyocardial ContractionMyocytes, CardiacPotassium Channels, Inwardly RectifyingKir2.1 channelPotassium Channels, Inwardly Rectifyingco-cultureelectrophysiologyHEKhiCMsIK1maturation

Identifiers

PMID34205607
PMCPMC8235371
OpenAlexW3176651198

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.