Evidence map›Paper›PMID 34205599›Full record

ArticleInternational journal of molecular sciences2021

Functionalization of Photosensitized Silica Nanoparticles for Advanced Photodynamic Therapy of Cancer.

Ruth Prieto-Montero, Alejandro Prieto-Castañeda, Alberto Katsumiti, Miren P Cajaraville, Antonia R Agarrabeitia, María J Ortiz, Virginia Martínez-Martínez

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. A Review of Silica-Based Nanoplatforms for Anticancer Cargo Delivery.International journal of molecular sciences · 2025
    Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Nanomaterials in Cancer Diagnosis and Therapy.International journal of molecular sciences · 2022
    Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ruth Prieto-MonteroDepartamento de Química Física, Universidad del País Vasco/Euskal Herriko Unibertsitatea (UPV/EHU), 48080 Bilbao, Spain.ORCID 0000-0001-6372-563X
Alejandro Prieto-CastañedaDepartamento de Química Orgánica, Facultad de CC. Químicas, Universidad Complutense de Madrid, 28040 Madrid, Spain.ORCID 0000-0002-7032-126X
Alberto KatsumitiCBET Research Group, Department Zoology and Animal Cell Biology, Faculty of Science and Technology and Research Centre for Experimental Marine Biology and Biotechnology PiE, University of the Basque Country UPV/EHU, 48620 Basque Country, Spain.ORCID 0000-0003-4145-4853
Miren P CajaravilleCBET Research Group, Department Zoology and Animal Cell Biology, Faculty of Science and Technology and Research Centre for Experimental Marine Biology and Biotechnology PiE, University of the Basque Country UPV/EHU, 48620 Basque Country, Spain.
Antonia R AgarrabeitiaDepartamento de Química Orgánica, Facultad de CC. Químicas, Universidad Complutense de Madrid, 28040 Madrid, Spain.
María J OrtizDepartamento de Química Orgánica, Facultad de CC. Químicas, Universidad Complutense de Madrid, 28040 Madrid, Spain.ORCID 0000-0002-0394-4045
Virginia Martínez-MartínezDepartamento de Química Física, Universidad del País Vasco/Euskal Herriko Unibertsitatea (UPV/EHU), 48080 Bilbao, Spain.ORCID 0000-0001-7551-3714

Funding

Euskal Herriko Unibertsitatea COLAB19/01Eusko Jaurlaritza IT-1302-19Eusko Jaurlaritza IT912-16Ministerio de Economía, Industria y Competitividad, Gobierno de España CTM2016-81130-RMinisterio de Economía, Industria y Competitividad, Gobierno de España MAT2017-83856-C3-2-PMinisterio de Economía, Industria y Competitividad, Gobierno de España MAT2017-83856-C3-3-PMinisterio de Economía, Industria y Competitividad, Gobierno de España PID2020-114755GB-C3
6 · The paper itself

Abstract

BODIPY dyes have recently attracted attention as potential photosensitizers. In this work, commercial and novel photosensitizers (PSs) based on BODIPY chromophores (haloBODIPYs and orthogonal dimers strategically designed with intense bands in the blue, green or red region of the visible spectra and high singlet oxygen production) were covalently linked to mesoporous silica nanoparticles (MSNs) further functionalized with PEG and folic acid (FA). MSNs approximately 50 nm in size with different functional groups were synthesized to allow multiple alternatives of PS-PEG-FA decoration of their external surface. Different combinations varying the type of PS (commercial Rose Bengal, Thionine and Chlorine e6 or custom-made BODIPY-based), the linkage design, and the length of PEG are detailed. All the nanosystems were physicochemically characterized (morphology, diameter, size distribution and PS loaded amount) and photophysically studied (absorption capacity, fluorescence efficiency, and singlet oxygen production) in suspension. For the most promising PS-PEG-FA silica nanoplatforms, the biocompatibility in dark conditions and the phototoxicity under suitable irradiation wavelengths (blue, green, or red) at regulated light doses (10-15 J/cm

Indexed as

NanoparticlesPhotochemotherapyRose BengalDrug Screening Assays, AntitumorFolic AcidHeLa CellsHumansNeoplasmsPolyethylene GlycolsSilicon DioxideFolic AcidPolyethylene GlycolsRose BengalSilicon DioxideBODIPY-based photosensitizersfolic acidfunctionalized silica nanoparticlesHeLa cellsPEGphotodynamic therapy(photo) toxicity

Identifiers

PMID34205599
PMCPMC8234454

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.