Evidence map›Paper›PMID 34205537›Full record

ArticleNutrients2021

Untargeted Plasma Metabolomics Unravels a Metabolic Signature for Tissue Sensitivity to Glucocorticoids in Healthy Subjects: Its Implications in Dietary Planning for a Healthy Lifestyle.

Nicolas C Nicolaides, Maria-Konstantina Ioannidi, Eleni Koniari, Ifigeneia Papageorgiou, Anastasia Bartzeliotou, Amalia Sertedaki, Maria I Klapa, Evangelia Charmandari

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Nicolas C NicolaidesDivision of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, Νational and Kapodistrian University of Athens Medical School, 'Aghia Sophia' Children's Hospital, 11527 Athens, Greece.
Maria-Konstantina IoannidiMetabolic Engineering and Systems Biology Laboratory, Institute of Chemical Engineering Sciences, Foundation for Research and Technology-Hellas (FORTH/ICE-HT), 26504 Patras, Greece.ORCID 0000-0001-7914-8363
Eleni KoniariDivision of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, Νational and Kapodistrian University of Athens Medical School, 'Aghia Sophia' Children's Hospital, 11527 Athens, Greece.
Ifigeneia PapageorgiouDivision of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, Νational and Kapodistrian University of Athens Medical School, 'Aghia Sophia' Children's Hospital, 11527 Athens, Greece.
Anastasia BartzeliotouDepartment of Clinical Biochemistry, Νational and Kapodistrian University of Athens Medical School, 'Aghia Sophia' Children's Hospital, 11527 Athens, Greece.
Amalia SertedakiDivision of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, Νational and Kapodistrian University of Athens Medical School, 'Aghia Sophia' Children's Hospital, 11527 Athens, Greece.
Maria I KlapaMetabolic Engineering and Systems Biology Laboratory, Institute of Chemical Engineering Sciences, Foundation for Research and Technology-Hellas (FORTH/ICE-HT), 26504 Patras, Greece.ORCID 0000-0002-2047-3185
Evangelia CharmandariDivision of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, Νational and Kapodistrian University of Athens Medical School, 'Aghia Sophia' Children's Hospital, 11527 Athens, Greece.ORCID 0000-0002-0851-6998
National and Kapodistrian University of Athens · GRFoundation for Research and Technology Hellas · GRUniversity of Patras · GR

Funding

The clinical study has been co-financed by the European Regional Development Fund of the European Union and Greek national funds through the Operational Program Competitiveness, Entrepreneurship and Innovation, under the call RESEARCH - CREATE - INNOVATE (project code: T1EDK-01386, MIS: 5030543, Acronym: PEDOBESITY)
6 · The paper itself

Abstract

In clinical practice, differences in glucocorticoid sensitivity among healthy subjects may influence the outcome and any adverse effects of glucocorticoid therapy. Thus, a fast and accurate methodology that could enable the classification of individuals based on their tissue glucocorticoid sensitivity would be of value. We investigated the usefulness of untargeted plasma metabolomics in identifying a panel of metabolites to distinguish glucocorticoid-resistant from glucocorticoid-sensitive healthy subjects who do not carry mutations in the human glucocorticoid receptor (

Indexed as

DietHealthy LifestyleMetabolomeAdrenocorticotropic HormoneAdultDexamethasoneFemaleGlucocorticoidsHumansHydrocortisoneMaleReceptors, GlucocorticoidYoung AdultAdrenocorticotropic HormoneDexamethasoneGlucocorticoidsHydrocortisoneNR3C1 protein, humanReceptors, Glucocorticoidblood plasma metabolic signaturedietary planningglucocorticoid receptorprecision medicinetissue glucocorticoid sensitivity in healthy adultsuntargeted GC–MS metabolomics

Identifiers

PMID34205537
PMCPMC8234096
OpenAlexW3173562740

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.