Evidence map›Paper›PMID 34205446›Full record

ArticleMolecules (Basel, Switzerland)2021

Temperature-Dependent Dynamical Evolution in Coum/SBE-β-CD Inclusion Complexes Revealed by Two-Dimensional FTIR Correlation Spectroscopy (2D-COS).

Giuseppe Paladini, Francesco Caridi, Vincenza Crupi, Federica De Gaetano, Domenico Majolino, Silvana Tommasini, Cinzia Anna Ventura, Valentina Venuti, Rosanna Stancanelli

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Gold nanoparticles incorporating rutin hydrate for targeting oxidative stress-driven neurodegeneration.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Giuseppe PaladiniDipartimento di Scienze Matematiche e Informatiche, Scienze Fisiche e Scienze della Terra, Università degli Studi di Messina, Viale Ferdinando Stagno D'Alcontres 31, 98166 Messina, Italy.ORCID 0000-0001-7446-0817
Francesco CaridiDipartimento di Scienze Matematiche e Informatiche, Scienze Fisiche e Scienze della Terra, Università degli Studi di Messina, Viale Ferdinando Stagno D'Alcontres 31, 98166 Messina, Italy.ORCID 0000-0002-3562-6244
Vincenza CrupiDipartimento di Scienze Chimiche, Biologiche, Farmaceutiche e Ambientali, Università degli Studi di Messina, Viale Ferdinando Stagno D'Alcontres 31, 98166 Messina, Italy.ORCID 0000-0003-3545-6289
Federica De GaetanoDipartimento di Scienze Chimiche, Biologiche, Farmaceutiche e Ambientali, Università degli Studi di Messina, Viale Ferdinando Stagno D'Alcontres 31, 98166 Messina, Italy.
Domenico MajolinoDipartimento di Scienze Matematiche e Informatiche, Scienze Fisiche e Scienze della Terra, Università degli Studi di Messina, Viale Ferdinando Stagno D'Alcontres 31, 98166 Messina, Italy.ORCID 0000-0002-2934-2587
Silvana TommasiniDipartimento di Scienze Chimiche, Biologiche, Farmaceutiche e Ambientali, Università degli Studi di Messina, Viale Ferdinando Stagno D'Alcontres 31, 98166 Messina, Italy.
Cinzia Anna VenturaDipartimento di Scienze Chimiche, Biologiche, Farmaceutiche e Ambientali, Università degli Studi di Messina, Viale Ferdinando Stagno D'Alcontres 31, 98166 Messina, Italy.ORCID 0000-0002-8743-2046
Valentina VenutiDipartimento di Scienze Matematiche e Informatiche, Scienze Fisiche e Scienze della Terra, Università degli Studi di Messina, Viale Ferdinando Stagno D'Alcontres 31, 98166 Messina, Italy.ORCID 0000-0003-2907-9165
Rosanna StancanelliDipartimento di Scienze Chimiche, Biologiche, Farmaceutiche e Ambientali, Università degli Studi di Messina, Viale Ferdinando Stagno D'Alcontres 31, 98166 Messina, Italy.ORCID 0000-0002-8670-7685

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A combination of Fourier transform infrared spectroscopy in attenuated total reflectance geometry (FTIR-ATR) and 2D correlation analysis (2D-COS) was applied here for the first time in order to investigate the temperature-dependent dynamical evolution occurring in a particular type of inclusion complex, based on sulfobutylether-β-cyclodextrin (SBE-β-CD) as hosting agent and Coumestrol (7,12-dihydorxcoumestane, Coum), a poorly-soluble active compound known for its anti-viral and anti-oxidant activity. For this purpose, synchronous and asynchronous 2D spectra were calculated in three different wavenumber regions (960-1320 cm

Indexed as

AntioxidantsAntiviral Agentsbeta-CyclodextrinsCoumestrolDrug CarriersSpectroscopy, Fourier Transform InfraredTemperatureAntioxidantsAntiviral Agentsbeta-CyclodextrinsCoumestrolDrug CarriersSBE4-beta-cyclodextrin2D correlation spectroscopyFTIR-ATRinclusion complexmolecular motionstemperature effecttime sequence

Identifiers

PMID34205446
PMCPMC8234892

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.