Evidence map›Paper›PMID 34205419›Full record

ArticleInternational journal of molecular sciences2021

VEGF-R2/Caveolin-1 Pathway of Undifferentiated ARPE-19 Retina Cells: A Potential Target as Anti-VEGF-A Therapy in Wet AMD by Resvega, an Omega-3/Polyphenol Combination.

Flavie Courtaut, Alessandra Scagliarini, Virginie Aires, Clarisse Cornebise, Jean-Paul Pais de Barros, Céline Olmiere, Dominique Delmas

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Flavie CourtautUniversité de Bourgogne Franche-Comté, 21000 Dijon, France.
Alessandra ScagliariniUniversité de Bourgogne Franche-Comté, 21000 Dijon, France.
Virginie AiresUniversité de Bourgogne Franche-Comté, 21000 Dijon, France.
Clarisse CornebiseUniversité de Bourgogne Franche-Comté, 21000 Dijon, France.ORCID 0000-0003-0038-3809
Jean-Paul Pais de BarrosUniversité de Bourgogne Franche-Comté, 21000 Dijon, France.
Céline OlmiereLaboratoires Thea, 12 Rue Louis-Blériot, 63000 Clermont-Ferrand, France.ORCID 0000-0001-7551-1129
Dominique DelmasUniversité de Bourgogne Franche-Comté, 21000 Dijon, France.
Inserm · FRThea (France) · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Age-related macular degeneration (AMD) is one of the main causes of deterioration in vision in adults aged 55 and older. In spite of therapies, the progression of the disease is often observed without reverse vision quality. In the present study, we explored whether, in undifferentiated ARPE-19 retinal cells, a disruption of the VEGF receptors (VEGF-R)/caveolin-1 (Cav-1)/protein kinases pathway could be a target for counteracting VEGF secretion. We highlight that Resvega

Indexed as

Caveolin 1Cell LineDrug Evaluation, PreclinicalHumansMacular DegenerationMAP Kinase Signaling SystemRetinaTranscription Factor AP-1Vascular Endothelial Growth Factor Receptor-2Caveolin 1KDR protein, humanTranscription Factor AP-1Vascular Endothelial Growth Factor Receptor-2AMDangiogenesisocular diseasesomega-3 fatty acidsresveratrolVEGFVEGF-receptor

Identifiers

PMID34205419
PMCPMC8234996
OpenAlexW3174973673

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.