Evidence map›Paper›PMID 34205390›Full record

ArticleBiology2021

Significance of BK Polyomavirus in Long-Term Survivors after Adult Allogeneic Stem Cell Transplantation.

Thomas Neumann, Nandette Peters, Jennifer Kranz, Desiree L Dräger, Florian H Heidel, William Krüger, Laila Schneidewind

Open access · goldAbstract read
In one paragraph

Article in Biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Thomas NeumannDepartment of Hematology/Oncology, University Medical Center Greifswald, 17475 Greifswald, Germany.ORCID 0000-0003-1160-1277
Nandette PetersDepartment of Hematology/Oncology, University Medical Center Greifswald, 17475 Greifswald, Germany.
Jennifer KranzDepartment of Urology and Kidney Transplantation, Martin-Luther-University, 06120 Halle/Saale, Germany.
Desiree L DrägerDepartment of Urology, University Medical Center Rostock, 18055 Rostock, Germany.
Florian H HeidelDepartment of Hematology/Oncology, University Medical Center Greifswald, 17475 Greifswald, Germany.ORCID 0000-0003-2438-1955
William KrügerDepartment of Hematology/Oncology, University Medical Center Greifswald, 17475 Greifswald, Germany.ORCID 0000-0003-3427-3632
Laila SchneidewindDepartment of Urology, University Medical Center Rostock, 18055 Rostock, Germany.ORCID 0000-0002-3409-8654
Universitätsmedizin Greifswald · DEUniversity of Rostock · DESankt-Antonius-Hospital Eschweiler · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAllogeneic stem cell transplantation (aSCT) is a common treatment for a variety of hematological diseases. Advances in transplantation practices have led to an increasing number of long-term aSCT survivors, but data about health status and late complications are sparse. This analysis focusses on kidney function and urological complications in this population.

methodsThis study is a prospective unicentric non-interventional trial. Before starting the study, we obtained the approval of the local ethics review board. Furthermore, the study was registered at WHO Clinical Trial Registry. The study protocol is available via UTN.

resultsWe were able to include 33 patients with a mean age of 60.5 years (SD 11.1). The median survival time following allogeneic stem cell transplantation was 9.0 years (IQR 8.5-13.0). Five patients (15.2%) had BKPyV viruria with mean 218.3 (SD 674.2) copies/mL. BKPyV viruria was significantly linked to pre-existing chronic kidney failure (

conclusionsBKPyV-associated nephropathy might be one reason for impaired kidney function in long-term survivors of aSCT.

Indexed as

allogeneic stem cell transplantationBK polyomavirus (BKPyV)chronic kidney disease

Identifiers

PMID34205390
PMCPMC8234795
OpenAlexW3175857033

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.