Evidence map›Paper›PMID 34205378›Full record

ReviewCancers2021

Microbiota Alterations in Precancerous Colon Lesions: A Systematic Review.

Francesca Aprile, Giovanni Bruno, Rossella Palma, Maria Teresa Mascellino, Cristina Panetta, Giulia Scalese, Alessandra Oliva, Carola Severi, Stefano Pontone

Registry-linked trialAbstract readReview
In one paragraph

Review in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06172647 (Intestinal Microbiome Adherent to the Mucosa in Microscopic Colitis in Comparison With Patients With Advanced Colon Adenomas), which is not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06172647 unknown statusnot on this mapstarted 2022, after this paper: background citation

Intestinal Microbiome Adherent to the Mucosa in Microscopic Colitis in Comparison With Patients With Advanced Colon Adenomas

TypeobservationalSponsorHospital Mutua de TerrassaRan2022 to 2025Enrolled60ConditionsMicroscopic Colitis, Colorectal Cancer, Colon AdenomaArmsColonoscopy
3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Prospective and Cross-sectional Associations of the Rectal Tissue Microbiome with Colorectal Adenoma Recurrence.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023
    Trial
  2. Article
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  5. Article
  6. Review
  7. Article
  8. Association ofHeliyon · 2023
    Article
  9. Review
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  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Francesca AprileDepartment of Translational and Precision Medicine, Gastroenterology Unit, Sapienza University of Rome, 00161 Rome, Italy.
Giovanni BrunoDepartment of Translational and Precision Medicine, Gastroenterology Unit, Sapienza University of Rome, 00161 Rome, Italy.
Rossella PalmaDepartment of Surgical Sciences, Sapienza University of Rome, 00161 Rome, Italy.
Maria Teresa MascellinoDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0001-7684-3088
Cristina PanettaDepartment of Surgical Sciences, Sapienza University of Rome, 00161 Rome, Italy.
Giulia ScaleseDepartment of Translational and Precision Medicine, Gastroenterology Unit, Sapienza University of Rome, 00161 Rome, Italy.
Alessandra OlivaDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0003-0832-7975
Carola SeveriDepartment of Translational and Precision Medicine, Gastroenterology Unit, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0001-9249-1318
Stefano PontoneDepartment of Surgical Sciences, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0001-7148-3220

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gut microbiota plays an important role in human health. It may promote carcinogenesis and is related to several diseases of the gastrointestinal tract. This study of microbial dysbiosis in the etiology of colorectal adenoma aimed to investigate the possible causative role of microbiota in the adenoma-carcinoma sequence and its possible preventive role. A systematic, PRISMA-guided review was performed. The PubMed database was searched using "adenoma microbiota" and selecting original articles between January 2010 and May 2020 independently screened. A higher prevalence of Proteobacteria, Fusobacteria, and Bacteroidetes phyla was observed in the fecal luminal and mucosa-associated microbiota of patients with adenoma. However, other studies provided evidence of depletion of

Indexed as

adenomaBacteroidescolorectal cancerendoscopyFusobacteriagutmetabolomicsmicrobiotapolypProteobacteria

Identifiers

PMID34205378
PMCPMC8234190

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.