Evidence map›Paper›PMID 34205356›Full record

ReviewNutrients2021

Visceral Adiposity and Cancer: Role in Pathogenesis and Prognosis.

Lucilla Crudele, Elena Piccinin, Antonio Moschetta

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 3 pooled it
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 3 syntheses or guidelines pooled it, 96 citations in OpenAlex.

  1. Life Course Trajectories of Body Mass Index and Risk of Cancer in Adulthood: Systematic Review and Meta-Analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
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  4. Anthropometric factors, physical activity, and the risk of soft tissue sarcoma: a case-control study.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2026
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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Lucilla CrudeleDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0002-0541-6211
Elena PiccininDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0002-6514-2689
Antonio MoschettaDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.
University of Bari Aldo Moro · ITIstituto Tumori Bari · IT

Funding

Associazione Italiana per la Ricerca sul Cancro AIRC IG 2019 Id. 23239Horizon 2020 Framework Programme Interreg V-A Greece-Italy 2014-2020- SILVER WELLBEING, MIS5003627Joint Programming Initiative A healthy diet for a healthy life HDHL-INTIMIC EuJPI-FATMAL;Ministero dell'Istruzione, dell'Università e della Ricerca MIUR PON "R&I" 2014-2020 n. ARS01_01220.Ministero dell'Istruzione, dell'Università e della Ricerca MIUR-PRIN 2017 n.2017J3E2W2;Ministero dell'Istruzione, dell'Università e della Ricerca PON AIM1853334 - Attività 2, linea 1.
6 · The paper itself

Abstract

The prevalence of being overweight and obese has been expanded dramatically in recent years worldwide. Obesity usually occurs when the energetic introit overtakes energy expenditure from metabolic and physical activity, leading to fat accumulation mainly in the visceral depots. Excessive fat accumulation represents a risk factor for many chronic diseases, including cancer. Adiposity, chronic low-grade inflammation, and hyperinsulinemia are essential factors of obesity that also play a crucial role in tumor onset. In recent years, several strategies have been pointed toward boundary fat accumulation, thus limiting the burden of cancer attributable to obesity. While remodeling fat via adipocytes browning seems a tempting prospect, lifestyle interventions still represent the main pathway to prevent cancer and enhance the efficacy of treatments. Specifically, the Mediterranean Diet stands out as one of the best dietary approaches to curtail visceral adiposity and, therefore, cancer risk. In this Review, the close relationship between obesity and cancer has been investigated, highlighting the biological mechanisms at the basis of this link. Finally, strategies to remodel fat, including browning and lifestyle interventions, have been taken into consideration as a major perspective to limit excess body weight and tumor onset.

Indexed as

AdipokinesAnimalsDietDiet, MediterraneanExerciseFemaleHumansInflammationInsulin ResistanceLife StyleMaillard ReactionMaleNeoplasmsObesityObesity, AbdominalPrognosisAdipokinescancerfastinglifestyle interventionsMediterranean dietobesityvisceral adiposity

Identifiers

PMID34205356
PMCPMC8234141
OpenAlexW3176090126

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.