Evidence map›Paper›PMID 34205017›Full record

ReviewLife (Basel, Switzerland)2021

Altered Bone Status in Rett Syndrome.

Alessandra Pecorelli, Valeria Cordone, Maria Lucia Schiavone, Carla Caffarelli, Carlo Cervellati, Gaetana Cerbone, Stefano Gonnelli, Joussef Hayek, Giuseppe Valacchi

Open access · goldAbstract readReview
In one paragraph

Review in Life (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. MECP2 Insufficiency Attenuates RUNX2-Dependent Osteoblast Differentiation via miR-126-3p/DKK1-Mediated Canonical Wnt Signaling Inhibition in Rett Syndrome.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  3. Article
  4. Article
  5. The Management of Bone Defects in Rett Syndrome.Calcified tissue international · 2025
    Review
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Alessandra PecorelliAnimal Science Department, Plants for Human Health Institute, North Carolina State University, Kannapolis, NC 28081, USA.ORCID 0000-0002-5207-068X
Valeria CordoneDepartment of Neuroscience and Rehabilitation, University of Ferrara, 44121 Ferrara, Italy.
Maria Lucia SchiavoneAnimal Science Department, Plants for Human Health Institute, North Carolina State University, Kannapolis, NC 28081, USA.ORCID 0000-0001-6728-3701
Carla CaffarelliDepartment of Medicine, Surgery and Neuroscience, University of Siena, Policlinico Le Scotte, 53100 Siena, Italy.
Carlo CervellatiDepartment of Translational Medicine and for Romagna, University of Ferrara, 44121 Ferrara, Italy.
Gaetana CerboneDivision of Medical Genetics, "S.G. Moscati" Hospital, 74100 Avellino, Italy.
Stefano GonnelliDepartment of Medicine, Surgery and Neuroscience, University of Siena, Policlinico Le Scotte, 53100 Siena, Italy.
Joussef HayekToscana Life Sciences Foundation, 53100 Siena, Italy.
Giuseppe ValacchiAnimal Science Department, Plants for Human Health Institute, North Carolina State University, Kannapolis, NC 28081, USA.
North Carolina State University · USUniversity of Ferrara · ITUniversity of Siena · ITAzienda Ospedaliera S.Giuseppe Moscati · ITToscana Life Sciences · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rett syndrome (RTT) is a monogenic neurodevelopmental disorder primarily caused by mutations in X-linked

Indexed as

bone metabolismbone mineral densityMeCP2osteoblastWNT pathway

Identifiers

PMID34205017
PMCPMC8230033
OpenAlexW3169046443

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.