Evidence map›Paper›PMID 34205005›Full record

ArticleCancers2021

A Novel Nodule Edge Sharpness Radiomic Biomarker Improves Performance of Lung-RADS for Distinguishing Adenocarcinomas from Granulomas on Non-Contrast CT Scans.

Mehdi Alilou, Prateek Prasanna, Kaustav Bera, Amit Gupta, Prabhakar Rajiah, Michael Yang, Frank Jacono, Vamsidhar Velcheti, Robert Gilkeson, Philip Linden and 1 more

Abstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Feature selection methods and predictive models in CT lung cancer radiomics.Journal of applied clinical medical physics · 2023
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mehdi AlilouDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.
Prateek PrasannaDepartment of Biomedical Informatics, Stony Brook University, Stony Brook, NY 11794, USA.ORCID 0000-0002-3068-3573
Kaustav BeraDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.
Amit GuptaUniversity Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, OH 44106, USA.
Prabhakar RajiahDepartment of Radiology, Mayo Clinic, Rochester, MN 55970, USA.
Michael YangUniversity Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, OH 44106, USA.
Frank JaconoUniversity Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, OH 44106, USA.
Vamsidhar VelchetiLaura and Isaac Perlmutter Cancer Center, NYU Langone, New York, NY 10016, USA.
Robert GilkesonUniversity Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, OH 44106, USA.
Philip LindenUniversity Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, OH 44106, USA.
Anant MadabhushiDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.ORCID 0000-0002-5741-0399

Funding

Pathology CoreU54CA254566 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI MADABHUSHI, ANANT · 2020 to 2024
$5.0M
Oral Cavity Quantitative Histomorphometric Risk Classifier (OHbIC) in Oral Cavity Squamous Cell Carcinoma (OC-SCC)R01CA249992 · NCI · EMORY UNIVERSITY · PI LEWIS, JAMES, MADABHUSHI, ANANT · 2021 to 2025
$3.2M
Computerized histologic image predictor of cancer outcomeR01CA202752 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI FELDMAN, MICHAEL D, GANESAN, SHRIDAR · 2016 to 2020
$3.1M
Quantitative Histomorphometric Risk Classifier (QuHbIC) in HPV + Oropharyngeal CarcinomaR01CA220581 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI KOYFMAN, SHLOMO, LEWIS, JAMES · 2018 to 2023
$3.1M
Computerized Histologic Risk Predictor (CHiRP) for Early Stage Lung CancersR01CA216579 · NCI · EMORY UNIVERSITY · PI FU, PINGFU, LLOYD, MARK · 2018 to 2023
$3.1M
MR Fingerprinting and Computerized Decision Support for Prostate CancerR01CA208236 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GULANI, VIKAS, PONSKY, LEE EVAN · 2017 to 2022
$3.0M
Pathology Image Informatics Platform for visualization, analysis and managementU24CA199374 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI GURCAN, METIN NAFI, MADABHUSHI, ANANT · 2015 to 2019
$2.9M
Novel Radiomics for Predicting Response to Immunotherapy for Lung CancerR01CA257612 · NCI · EMORY UNIVERSITY · PI Anant Madabhushi, Vamsidhar Velcheti · 2021 to 2026
$2.7M
RadxTools for assessing tumor treatment response on imagingU01CA248226 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI TIWARI, PALLAVI, VISWANATH, SATISH EASWAR · 2020 to 2022
$1.4M
HistoTools: A suite of digital pathology tools for quality control, annotation and dataset identificationU01CA239055 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI JANOWCZYK, ANDREW ROBERT, MADABHUSHI, ANANT · 2019 to 2022
$1.0M
NCI NIH HHS 1U01CA239055-01NCI NIH HHS 1U01CA248226-01NCI NIH HHS 1U24CA199374-01NCI NIH HHS 1U54CA254566-01NCI NIH HHS R01CA202752-01A1NCI NIH HHS R01CA208236-01A1NCI NIH HHS R01CA216579-01A1NCI NIH HHS R01CA220581-01A1NCI NIH HHS R01CA249992-01A1NCI NIH HHS R01CA257612-01A1U.S. Department of Defense W81XWH-18-1-0440U.S. Department of Defense W81XWH-20-1-0595
6 · The paper itself

Abstract

The aim of this study is to evaluate whether NIS radiomics can distinguish lung adenocarcinomas from granulomas on non-contrast CT scans, and also to improve the performance of Lung-RADS by reclassifying benign nodules that were initially assessed as suspicious. The screening or standard diagnostic non-contrast CT scans of 362 patients was divided into training (S

Indexed as

CT imageslung nodule classificationlung-RADSnodule interface sharpnessnodule risk score

Identifiers

PMID34205005
PMCPMC8199879

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.