Evidence map›Paper›PMID 34204996›Full record

ArticleJournal of personalized medicine2021

Olfactory Bulb Proteomics Reveals Widespread Proteostatic Disturbances in Mixed Dementia and Guides for Potential Serum Biomarkers to Discriminate Alzheimer Disease and Mixed Dementia Phenotypes.

Mercedes Lachén-Montes, Ignacio Íñigo-Marco, Paz Cartas-Cejudo, Joaquín Fernández-Irigoyen, Enrique Santamaría

Open access · goldAbstract read
In one paragraph

Article in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Mercedes Lachén-MontesClinical Neuroproteomics Unit, Navarrabiomed, Complejo Hospitalario de Navarra (CHN), Universidad Pública de Navarra (UPNA), Navarra Institute for Health Research (IdiSNA), Irunlarrea, 3, 31008 Pamplona, Spain.
Ignacio Íñigo-MarcoClinical Neuroproteomics Unit, Navarrabiomed, Complejo Hospitalario de Navarra (CHN), Universidad Pública de Navarra (UPNA), Navarra Institute for Health Research (IdiSNA), Irunlarrea, 3, 31008 Pamplona, Spain.
Paz Cartas-CejudoClinical Neuroproteomics Unit, Navarrabiomed, Complejo Hospitalario de Navarra (CHN), Universidad Pública de Navarra (UPNA), Navarra Institute for Health Research (IdiSNA), Irunlarrea, 3, 31008 Pamplona, Spain.ORCID 0000-0002-6182-7445
Joaquín Fernández-IrigoyenClinical Neuroproteomics Unit, Navarrabiomed, Complejo Hospitalario de Navarra (CHN), Universidad Pública de Navarra (UPNA), Navarra Institute for Health Research (IdiSNA), Irunlarrea, 3, 31008 Pamplona, Spain.ORCID 0000-0001-5072-4099
Enrique SantamaríaClinical Neuroproteomics Unit, Navarrabiomed, Complejo Hospitalario de Navarra (CHN), Universidad Pública de Navarra (UPNA), Navarra Institute for Health Research (IdiSNA), Irunlarrea, 3, 31008 Pamplona, Spain.ORCID 0000-0001-8046-8102
Universidad Publica de Navarra · ES

Funding

Department of Economic and Business Development from Government of Navarra 0011-1411-2020-000028Spanish Ministry of Science Innovation and Universities PID2019-110356RB-I00/ AEI / 10.13039/501100011033
6 · The paper itself

Abstract

The most common form of mixed dementia (MixD) is constituted by abnormal protein deposits associated with Alzheimer's disease (AD) that coexist with vascular disease. Although olfactory dysfunction is considered a clinical sign of AD-related dementias, little is known about the impact of this sensorial impairment in MixD at the molecular level. To address this gap in knowledge, we assessed olfactory bulb (OB) proteome-wide expression in MixD subjects (

Indexed as

Alzheimer’s diseasemixed dementiaolfactory bulbproteomicsvascular dementia

Identifiers

PMID34204996
PMCPMC8227984
OpenAlexW3159183857

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.