ReviewDentistry journal2021
Fluoride Varnishes for Preventing Occlusal Dental Caries: A Review.
Review in Dentistry journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06403371 (The Effect of Fluoride Varnish on White Spot Lesion in Clear Aligner Orthodontic Patients), which is not on this map. Cited by 54 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Fluoride Varnish on White Spot Lesion in Clear Aligner Orthodontic Patients: Prospective Randomized Controlled Clinical Trial
Who cites it
54 citing papers in PubMed, 2 syntheses or guidelines pooled it, 103 citations in OpenAlex.
- The Effectiveness of Topical Fluorides in Preventing Dental Caries in Children and Adolescents: A Systematic Review and Meta-Analysis.Oral health & preventive dentistry · 2026Pooled it
- [Meta-analysis of sealants versus fluoride varnishes for the prevention of occlusal surface caries in children's first permanent molars].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2025Pooled it
- Effect of Various Types of Remineralizing Agents on the Remineralization of Mild and Moderate Defects Caused by Molar-Incisor Hypomineralization in Mexican Schoolchildren: A 12-month Follow-up Randomized Clinical Trial.Oral health & preventive dentistry · 2026Trial
- Effectiveness of S-PRG-based varnish and bioactive glass-based air polishing in the management of dentin hypersensitivity and their effects on tooth color: a 12-month randomized clinical trial.BMC oral health · 2026Trial
- [Effectiveness and cost-effectiveness of risk-based topical fluoride intervention on early childhood caries in Jiangnan District, Nanning City].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2026Trial
- [Efficacy and cost analysis of two fluoride varnishes in community-based interventions for early childhood caries].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2026Trial
- Plaque and Salivary Fluoride Levels in Preschoolers Following Applications of Silver Diamine Fluoride, Sodium Fluoride Varnish, and Their Combination: A Randomized Clinical Trial.International journal of paediatric dentistry · 2026Trial
- Effectiveness of a School-Based Oral Health Promotion Program on Dental Caries Among Iraqi School Children: A Cluster Randomised Controlled Trial.International dental journal · 2025Trial
- A Randomized Controlled Trial to Evaluate and Compare the Effectiveness of Two Fluoride Varnishes Containing Casein Phosphopeptide-Amorphous Calcium Phosphate and Xylitol with Brushing Twice Daily Regimen in Preventing Dental Caries among 3-6-year-old Preschool Children.International journal of clinical pediatric dentistry · 2026Article
- Effect of Fluoride Varnishes Containing Casein Phosphopeptide-amorphous Calcium Phosphate on Primary Enamel Microhardness: AnInternational journal of clinical pediatric dentistry · 2026Article
- Comparative in vitro cytotoxicity of four commercially available 5% sodium fluoride varnishes in HGF-1 gingival fibroblasts.BMC oral health · 2026Article
- Integrated Dentist-Nurse Collaborative Care Model for Caries Management in China.Dentistry journal · 2026Review
- Oral Health Promotion Among Students in Special Education Schools: Protocol for a Multicity Cluster Randomized Controlled Trial.JMIR research protocols · 2026Article
- Comparative effects of fluoride-containing and remineralization-promoting agents on artificial gastric juice-induced bovine enamel erosion susceptibility: an in vitro study.BMC oral health · 2026Article
- Assessment of the remineralizing potential of nano-bioactive glass, nano-hydroxyapatite, and sodium fluoride on artificial carious lesions in primary teeth.BMC oral health · 2026Article
- Review
- The differences of enamel hardness post application of silver diamine fluoride and fluoride varnish on demineralized tooth surface (in vitro).Scientific reports · 2025Article
- Duration-Dependent Caries Risk During Clear Aligner Therapy: A Retrospective Analysis.Biomimetics (Basel, Switzerland) · 2025Article
- Microbiological Investigation and Clinical Efficacy of Professional Topical Fluoride Application onMicroorganisms · 2025Article
- Antibacterial activity and physicochemical properties of light-curable fluoride varnishes containing strontium phosphate-based glass.Clinical oral investigations · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dental caries are most likely to occur on occlusal surfaces from the early eruptive stages of the tooth. In children, about 80% to 90% of dental caries are occlusal caries. Different preventive modalities are used to prevent occlusal caries. One of the methods used for occlusal caries prevention is fluoride varnish. A vast number of clinical trials have evaluated several types of sealant material and fluoride varnish to assess their ability to prevent occlusal caries in both primary and permanent dentition. The purpose of the current study was to provide an updated overview of the development, composition, mechanism of action, application, and safety of fluoride varnish, as well as its effect on occlusal caries prevention. This review of recently published studies on fluoride varnish and its effect on occlusal caries prevention shows that in children at moderate to high risk of caries, fluoride varnishes prevent occlusal caries. Both resin-based fissure sealants and fluoride varnish are effective for occlusal caries prevention for first-permanent molars. However, it was not possible to identify which one has the best effect. It is recommend that fluoride varnish is applied for children at high risk of caries two to four times per year.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.