Evidence map›Paper›PMID 34204930›Full record

ArticleBiosensors2021

Surface Plasmon Resonance Assay for Label-Free and Selective Detection of HIV-1 p24 Protein.

Lucia Sarcina, Giuseppe Felice Mangiatordi, Fabrizio Torricelli, Paolo Bollella, Zahra Gounani, Ronald Österbacka, Eleonora Macchia, Luisa Torsi

Open access · goldAbstract read
In one paragraph

Article in Biosensors, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. The contemporary immunoassays for HIV diagnosis: a concise overview.Asian biomedicine : research, reviews and news · 2023
    Review
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Lucia SarcinaDipartimento di Chimica, Universita' degli Studi di Bari A. Moro, 70125 Bari, Italy.
Giuseppe Felice MangiatordiCNR-Institute of Crystallography, 70125 Bari, Italy.ORCID 0000-0003-4042-2841
Fabrizio TorricelliDipartimento di Ingegneria dell'Informazione, Università degli Studi di Brescia, 25123 Brescia, Italy.
Paolo BollellaDipartimento di Chimica, Universita' degli Studi di Bari A. Moro, 70125 Bari, Italy.ORCID 0000-0001-9049-6406
Zahra GounaniPhysics, Faculty of Science and Engineering, Åbo Akademi University, 20500 Turku, Finland.
Ronald ÖsterbackaPhysics, Faculty of Science and Engineering, Åbo Akademi University, 20500 Turku, Finland.ORCID 0000-0003-0656-2592
Eleonora MacchiaPhysics, Faculty of Science and Engineering, Åbo Akademi University, 20500 Turku, Finland.ORCID 0000-0002-1534-7336
Luisa TorsiDipartimento di Chimica, Universita' degli Studi di Bari A. Moro, 70125 Bari, Italy.
Åbo Akademi University · FIUniversity of Bari Aldo Moro · ITInstitute of Crystallography · ITUniversity of Brescia · IT

Funding

Academy of Finland 332106
6 · The paper itself

Abstract

The early detection of the human immunodeficiency virus (HIV) is of paramount importance to achieve efficient therapeutic treatment and limit the disease spreading. In this perspective, the assessment of biosensing assay for the HIV-1 p24 capsid protein plays a pivotal role in the timely and selective detection of HIV infections. In this study, multi-parameter-SPR has been used to develop a reliable and label-free detection method for HIV-1 p24 protein. Remarkably, both physical and chemical immobilization of mouse monoclonal antibodies against HIV-1 p24 on the SPR gold detecting surface have been characterized for the first time. The two immobilization techniques returned a capturing antibody surface coverage as high as (7.5 ± 0.3) × 10

Indexed as

HIV Core Protein p24Surface Plasmon ResonanceBiological AssayBiosensing TechniquesGoldHIV-1Limit of DetectionGoldHIV Core Protein p24HIV-1 p24 proteinlabel-free detectionsurface modificationssurface plasmon resonance

Identifiers

PMID34204930
PMCPMC8229864
OpenAlexW3166496866

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.